Search: onr:"swepub:oai:lup.lub.lu.se:a57c2e1a-c8f1-4551-b3dd-c1a92e34aeac" >
Pregnancy and risk ...
Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2
-
- Jernström, Helena (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Lerman, C (author)
-
Ghadirian, P (author)
-
show more...
-
Lynch, H T (author)
-
Weber, B (author)
-
Garber, J (author)
-
Daly, M (author)
-
Olopade, O I (author)
-
Foulkes, W D (author)
-
Warner, E (author)
-
Brunet, J S (author)
-
Narod, S A (author)
-
show less...
-
(creator_code:org_t)
- 1999
- 1999
- English.
-
In: The Lancet. - 1474-547X. ; 354:9193, s. 1846-1850
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Early age at first full-term pregnancy and increasing parity are associated with a reduced risk of breast cancer. However, whether pregnancy decreases the risk of early-onset hereditary breast cancer is unknown. There is concern that pregnancy may increase breast-cancer risk in carriers of BRCA1 and BRCA2 germline mutations. We aimed to establish whether pregnancy is a risk factor for hereditary breast cancer. METHODS: We did a matched case-control study of breast cancer in women who carry deleterious BRCA1 or BRCA2 mutations. Cases were carriers who developed breast cancer by age 40 years, and controls were carriers of the same age without breast cancer, or who were diagnosed with breast cancer after age 40 years. Women who had undergone preventive mastectomy, hysterectomy, or oophorectomy, or who were diagnosed with ovarian cancer before the age at which breast cancer was diagnosed in the matched case were excluded. Information about pregnancies and pregnancy outcome was derived from a questionnaire completed by women in the course of genetic counselling. FINDINGS: A higher proportion of cases than controls had had a full term pregnancy (173/236 vs 146/236; odds ratio 1.71 [95% CI 1.13-2.62], p=0.01). The mean number of births was also greater for cases than for controls (1.62 vs 1.38, p=0.04). The risk increased with the number of births and did not diminish with time since last pregnancy. There were no significant differences in age at first birth or age at last birth between cases and controls. INTERPRETATION: Carriers of the BRCA1 and BRCA2 mutations who have children are significantly more likely to develop breast cancer by age 40 than carriers who are nulliparous. Each pregnancy is associated with an increased cancer risk. An early first pregnancy does not confer protection for carriers of BRCA1 or BRCA2 mutations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
The Lancet
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Jernström, Helen ...
-
Lerman, C
-
Ghadirian, P
-
Lynch, H T
-
Weber, B
-
Garber, J
-
show more...
-
Daly, M
-
Olopade, O I
-
Foulkes, W D
-
Warner, E
-
Brunet, J S
-
Narod, S A
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
The Lancet
- By the university
-
Lund University