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Molecular mechanism...
Molecular mechanisms governing aquaporin relocalisation
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- Markou, Andrea (author)
- Aston University
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- Unger, Lucas (author)
- Aston University
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- Abir-Awan, Mohammed (author)
- Aston University
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- Saadallah, Ahmed (author)
- Aston University
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- Halsey, Andrea (author)
- University of Cambridge
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- Baklava, Zita (author)
- Aston University
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- Conner, Matthew (author)
- University of Wolverhampton
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- Törnroth-Horsefield, Susanna (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Greenhill, Stuart D. (author)
- Aston University
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- Conner, Alex (author)
- University of Birmingham
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- Bill, Roslyn M. (author)
- Aston University
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- Salman, Mootaz M. (author)
- University of Oxford
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- Kitchen, Philip (author)
- Aston University
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Biochimica et Biophysica Acta - Biomembranes. - : Elsevier BV. - 0005-2736. ; 1864:4
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Abstract
Subject headings
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- The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the movement of water across biological membrane by osmosis, as well as facilitating the diffusion of small polar solutes. AQPs have been recognised as drug targets for a variety of disorders associated with disrupted water or solute transport, including brain oedema following stroke or trauma, epilepsy, cancer cell migration and tumour angiogenesis, metabolic disorders, and inflammation. Despite this, drug discovery for AQPs has made little progress due to a lack of reproducible high-throughput assays and difficulties with the druggability of AQP proteins. However, recent studies have suggested that targetting the trafficking of AQP proteins to the plasma membrane is a viable alternative drug target to direct inhibition of the water-conducting pore. Here we review the literature on the trafficking of mammalian AQPs with a view to highlighting potential new drug targets for a variety of conditions associated with disrupted water and solute homeostasis.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- AQP
- Aquaporin
- Membrane trafficking
- Osmosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Markou, Andrea
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Unger, Lucas
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Abir-Awan, Moham ...
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Saadallah, Ahmed
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Halsey, Andrea
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Baklava, Zita
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show more...
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Conner, Matthew
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Törnroth-Horsefi ...
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Greenhill, Stuar ...
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Conner, Alex
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Bill, Roslyn M.
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Salman, Mootaz M ...
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Kitchen, Philip
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Biochimica et Bi ...
- By the university
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Lund University