Search: onr:"swepub:oai:lup.lub.lu.se:a5a631de-0f6f-49d7-9e9a-692359f7cd39" >
GSM 900 MHz exposur...
GSM 900 MHz exposure of Transgenic GFAP-Mice: A study of histopathology, Tumour induction and BBB leakage
-
- Salford, Leif (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Brun, Arne (author)
- Lund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Persson, Bertil R (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
(creator_code:org_t)
- 2012
- 2012
- English.
-
In: Acta Scientiarum Lundensia. - 1651-5013. ; 2012-003, s. 1-17
- Related links:
-
https://lup.lub.lu.s...
Abstract
Subject headings
Close
- Abstract. In previous work we have studied the effects of electromagnetic fields upon the promotion of growth of tumours from two different rat glioma cell lines, RG2 and N32, inoculated in the brains of Fischer 344 rats. No promotions of tumour growth due to the EMF could be demonstrated in large series of animals as compared to their matched controls. In the present study we have utilized a newly generated "knock-out" mouse model. By the use of gene targeting, Pekny et al. have created mice deficient for glial fibrillary acidic protein (GFAP), which is an astrocyte-specific protein that forms intermediate filaments in the cytoskeleton of astrocytes. The GFAP-deficient mice utilized by us develop spontaneous tumours, both lymphoblastic (non-Hodgkin) lymphomas and Anaplastic rapidly growing tumours diagnosed as malignant Swannomas. The test system consists of four TEM-cells. A GSM telephone is hooked up to a terminal program on a computer that controls the power and repetition of pulses. The rats were exposed for about 8 hours during 43 days for a total time of 1143 hours. In male GFAP-mice we found tumours in all 6 controls and in 4 out of 6 exposed. We found, however, no tumours in FM controls and in seven exposed FM mice we fund only 1 tumour. Microwave exposure revealed no significant effect on tumour evolution in the GFAP-mice. In the CBA-mice microwave exposure gave no significant results of BBB-leakage. But for the CBA-mice BBB-leakage after microwave exposure of CBA-mice was found probable at a 99% significance-level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- 900 MHz. exposure
- GFAP
- Transgenic Mice
- tumour induction
- BBB leakage
- GSM
Publication and Content Type
- art (subject category)
- vet (subject category)
Find in a library
To the university's database