Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

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Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

Mahamat-Saleh, Yahya (author): Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy

Cervenka, Iris (author): Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)

Al-Rahmoun, Marie (author): University of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)

Mancini, Francesca R. (author): Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy

Severi, Gianluca (author): University of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)

Ghiasvand, Reza (author): University of Oslo

Veierod, Marit B. (author): University of Oslo

Caini, Saverio (author): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Palli, Domenico (author): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Botteri, Edoardo (author): Oslo university hospital

Sacerdote, Carlotta (author): Centre for Cancer Epidemiology and Prevention (CPO Piemonte)

Ricceri, Fulvio (author): Azienda Sanitaria Locale Torino 3

Trichopoulou, Antonia (author): Hellenic Health Foundation, Athens

Peppa, Eleni (author): Hellenic Health Foundation, Athens

La Vecchia, Carlo (author): Hellenic Health Foundation, Athens,University of Milan

Overvad, Kim (author): Aalborg University Hospital,Aarhus University

Dahm, Christina C. (author): Aarhus University

Olsen, Anja (author): Danish Cancer Society

Tjønneland, Anne (author): Danish Cancer Society,University of Copenhagen

Perez-Cornago, Aurora (author): University of Oxford

Jakszyn, Paula (author): L'Hospitalet de Llobregat, Barcelona,Ramon Llull University

Grioni, Sara (author): Istituto Nazionale dei Tumori

Schulze, Matthias B. (author): German Institute of Human Nutrition,University of Potsdam

Skeie, Guri (author): UiT The Arctic University of Norway, Tromsø

Lasheras, Cristina (author): University of Oviedo

Colorado-Yohar, Sandra (author): CIBER Epidemiology and Public Health (CIBERESP),University of Antioquia,Murcia Regional Health Council

Rodríguez-Barranco, Miguel (author): University of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)

Kühn, Tilman (author): German Cancer Research Centre

Katzke, Verena A. (author): German Cancer Research Centre

Amiano, Pilar (author): CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute

Tumino, Rosario (author): Civic and M.P Arezzo Hospital

Panico, Salvatore (author): University of Naples Federico II

Ezponda, Ana (author): University Clinic of Navarra

Sonestedt, Emily (author): Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups

Scalbert, Augustin (author): International Agency for Research on Cancer, World Health Organization

Weiderpass, Elisabete (author): International Agency for Research on Cancer, World Health Organization

Boutron-Ruault, Marie Christine (author): University of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)

Kvaskoff, Marina (author): Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy,University of Paris-Saclay

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(creator_code:org_t)

2020-07-24
2020
English 11 s.
In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 35:11, s. 1057-1067

Related links:: http://dx.doi.org/10...; show more...; https://munin.uit.no...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific dietary questionnaires. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI). During a mean follow-up of 13.7 years, 8448 skin cancer cases were identified among 270,112 participants. We observed a positive linear dose–response relationship between total citrus intake and skin cancer risk (HR = 1.10, 95% CI 1.03–1.18 in the highest vs. lowest quartile; Ptrend = 0.001), particularly with basal cell carcinoma (BCC) (HR = 1.11, 95% CI 1.02–1.20, Ptrend = 0.007) and squamous cell carcinoma (SCC) (HR = 1.23, 95% CI 1.04–1.47, Ptrend = 0.01). Citrus fruit intake was positively associated with skin cancer risk (HR = 1.08, 95% CI 1.01–1.16, Ptrend = 0.01), particularly with melanoma (HR = 1.23, 95% CI 1.02–1.48; Ptrend = 0.01), although with no heterogeneity across skin cancer types (Phomogeneity = 0.21). Citrus juice was positively associated with skin cancer risk (Ptrend = 0.004), particularly with BCC (Ptrend = 0.008) and SCC (Ptrend = 0.004), but not with melanoma (Phomogeneity = 0.02). Our study suggests moderate positive linear dose–response relationships between citrus intake and skin cancer risk. Studies with available biomarker data and the ability to examine sun exposure behaviors are warranted to clarify these associations and examine the phototoxicity mechanisms of furocoumarin-rich foods.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

Citrus
Cohort studies
Cutaneous melanoma
Epidemiology
Keratinocyte cancers

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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By the university: Lund University

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