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Steroid glycosides ...
Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest
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- Duyen, Nguyen Thi (author)
- National Institute of Medicinal Materials, Vietnam
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- Vinh, Le Ba (author)
- Korea University,Vietnamese Academy of Science and Technology
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- Phong, Nguyen Viet (author)
- Vietnamese Academy of Science and Technology
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- Khoi, Nguyen Minh (author)
- National Institute of Medicinal Materials, Vietnam
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- Ha, Do Thi (author)
- National Institute of Medicinal Materials, Vietnam
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- Long, Pham Quoc (author)
- Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
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- Dung, Le Viet (author)
- Lund University
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- Hien, Tran Thi (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancerinfektion,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Cancer Infection,Lund University Research Groups
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- Dat, Nguyen Tien (author)
- Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
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- Lee, Ki Yong (author)
- Korea University
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Carbohydrate Research. - : Elsevier BV. - 0008-6215. ; 519
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http://dx.doi.org/10...
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Abstract
Subject headings
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- In our previous research on Vietnamese medicinal plants, we found that the ethanolic extract of the aerial parts of Paris polyphylla var. chinensis exhibited cytotoxic effects in vitro in the MCF-7 human cancer cell line. Here, we used combined chromatographic separations to isolate six compounds including a new steroid glycoside, paripoloside A (3), and five known compounds, from the butanol extract of the aerial parts of P. polyphylla. We unambiguously elucidated their structures based on spectroscopic data (proton and carbon-13 nuclear magnetic resonance, heteronuclear single quantum coherence, heteronuclear multiple bond correlation, correlation spectroscopy, and high-resolution electrospray ionization mass spectroscopy data), and chemical reactions. Among the isolated compounds, paris saponin II (PSII) had the strongest cytotoxic effects against MCF-7 breast cancer cells. Interestingly, PSII significantly increased the expression of p53, p21, p27, and Bax protein levels and significantly suppressed the expression of cyclin D1 and retinoblastoma protein. These data suggest that PSII may induce G1/S phase cell cycle arrest and apoptosis pathway development in MCF-7 cells. Furthermore, the MCF-7 breast cancer cells mechanism of PSII was also investigated using molecular docking. Together, our results demonstrate that isolated compounds from P. polyphylla are promising candidates as breast cancer inhibitors.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Breast cancer
- Cytotoxic activity
- Paripoloside A
- Paris polyphylla var. chinensis
- Steroid glycosides
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Duyen, Nguyen Th ...
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Vinh, Le Ba
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Phong, Nguyen Vi ...
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Khoi, Nguyen Min ...
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Ha, Do Thi
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Long, Pham Quoc
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Dung, Le Viet
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Hien, Tran Thi
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Dat, Nguyen Tien
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Lee, Ki Yong
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Carbohydrate Res ...
- By the university
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Lund University