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Quantitative flow r...
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Sejr-Hansen, MartinAarhus University Hospital
(author)
Quantitative flow ratio for immediate assessment of nonculprit lesions in patients with ST-segment elevation myocardial infarction—An iSTEMI substudy
- Article/chapterEnglish2019
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LIBRIS-ID:oai:lup.lub.lu.se:a772ac95-209a-4d65-bae5-4c3b0d92fbfd
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https://lup.lub.lu.se/record/a772ac95-209a-4d65-bae5-4c3b0d92fbfdURI
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https://doi.org/10.1002/ccd.28208DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Objectives: We evaluated the diagnostic performance of quantitative flow ratio (QFR) assessment of nonculprit lesions (NCLs) based on acute setting angiograms obtained in patients with ST-segment elevation myocardial infarction (STEMI) with QFR, fractional flow reserve (FFR), and instantaneous wave-free ratio (iFR) in the staged setting as reference. Background: QFR is an angiography-based approach for the functional evaluation of coronary artery lesions. Methods: This was a post-hoc analysis of the iSTEMI study. NCLs were assessed with iFR in the acute setting and with iFR and FFR at staged (median 13 days) follow-up. Acute and staged QFR values were computed in a core laboratory based on the coronary angiography recordings. Diagnostic cut-off values were ≤0.80 for QFR and FFR, and ≤0.89 for iFR. Results: Staged iFR and FFR data were available for 146 NCLs in 112 patients in the iSTEMI study. Among these, QFR analysis was feasible in 103 (71%) lesions assessed in the acute setting with a mean QFR value of 0.82 (IQR: 0.73–0.91). Staged QFR, FFR, and iFR were 0.80 (IQR: 0.70–0.90), 0.81 (IQR: 0.71–0.88), and 0.91 (IQR: 0.87–0.96), respectively. Classification agreement of acute and staged QFR was 93% (95%Cl: 87–99). The classification agreement of acute QFR was 84% (95%CI: 76–90) using staged FFR as reference and 74% (95%CI: 65–83) using staged iFR as reference. Conclusions: Acute QFR showed a very good diagnostic performance with staged QFR as reference, a good diagnostic performance with staged FFR as reference, and a moderate diagnostic performance with staged iFR as reference.
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Westra, JelmerAarhus University Hospital
(author)
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Thim, TroelsAarhus University Hospital
(author)
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Christiansen, Evald HøjAarhus University Hospital
(author)
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Eftekhari, AshkanAarhus University Hospital
(author)
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Kristensen, Steen DalbyAarhus University Hospital
(author)
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Jakobsen, LarsAarhus University Hospital
(author)
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Götberg, MatthiasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-mgo
(author)
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Frøbert, OleÖrebro University Hospital
(author)
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van der Hoeven, Nina W.Vrije Universiteit Amsterdam
(author)
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Holm, Niels RamsingAarhus University Hospital
(author)
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Maeng, MichaelAarhus University Hospital
(author)
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Aarhus University HospitalKardiologi
(creator_code:org_t)
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In:Catheterization and Cardiovascular Interventions: Wiley94:5, s. 686-6921522-19461522-726X
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Thim, Troels
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Jakobsen, Lars
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