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  • Sejr-Hansen, MartinAarhus University Hospital (author)

Quantitative flow ratio for immediate assessment of nonculprit lesions in patients with ST-segment elevation myocardial infarction—An iSTEMI substudy

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-03-25
  • Wiley,2019

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  • LIBRIS-ID:oai:lup.lub.lu.se:a772ac95-209a-4d65-bae5-4c3b0d92fbfd
  • https://lup.lub.lu.se/record/a772ac95-209a-4d65-bae5-4c3b0d92fbfdURI
  • https://doi.org/10.1002/ccd.28208DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objectives: We evaluated the diagnostic performance of quantitative flow ratio (QFR) assessment of nonculprit lesions (NCLs) based on acute setting angiograms obtained in patients with ST-segment elevation myocardial infarction (STEMI) with QFR, fractional flow reserve (FFR), and instantaneous wave-free ratio (iFR) in the staged setting as reference. Background: QFR is an angiography-based approach for the functional evaluation of coronary artery lesions. Methods: This was a post-hoc analysis of the iSTEMI study. NCLs were assessed with iFR in the acute setting and with iFR and FFR at staged (median 13 days) follow-up. Acute and staged QFR values were computed in a core laboratory based on the coronary angiography recordings. Diagnostic cut-off values were ≤0.80 for QFR and FFR, and ≤0.89 for iFR. Results: Staged iFR and FFR data were available for 146 NCLs in 112 patients in the iSTEMI study. Among these, QFR analysis was feasible in 103 (71%) lesions assessed in the acute setting with a mean QFR value of 0.82 (IQR: 0.73–0.91). Staged QFR, FFR, and iFR were 0.80 (IQR: 0.70–0.90), 0.81 (IQR: 0.71–0.88), and 0.91 (IQR: 0.87–0.96), respectively. Classification agreement of acute and staged QFR was 93% (95%Cl: 87–99). The classification agreement of acute QFR was 84% (95%CI: 76–90) using staged FFR as reference and 74% (95%CI: 65–83) using staged iFR as reference. Conclusions: Acute QFR showed a very good diagnostic performance with staged QFR as reference, a good diagnostic performance with staged FFR as reference, and a moderate diagnostic performance with staged iFR as reference.

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  • Westra, JelmerAarhus University Hospital (author)
  • Thim, TroelsAarhus University Hospital (author)
  • Christiansen, Evald HøjAarhus University Hospital (author)
  • Eftekhari, AshkanAarhus University Hospital (author)
  • Kristensen, Steen DalbyAarhus University Hospital (author)
  • Jakobsen, LarsAarhus University Hospital (author)
  • Götberg, MatthiasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-mgo (author)
  • Frøbert, OleÖrebro University Hospital (author)
  • van der Hoeven, Nina W.Vrije Universiteit Amsterdam (author)
  • Holm, Niels RamsingAarhus University Hospital (author)
  • Maeng, MichaelAarhus University Hospital (author)
  • Aarhus University HospitalKardiologi (creator_code:org_t)

Related titles

  • In:Catheterization and Cardiovascular Interventions: Wiley94:5, s. 686-6921522-19461522-726X

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