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Defining the contri...
Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium
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- Grommisch, David (author)
- Karolinska Institutet,Karolinska Institute
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- Wang, Menghan (author)
- Karolinska Institute
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- Eenjes, Evelien (author)
- Karolinska Institute
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- Svetličič, Maja (author)
- Karolinska Institute
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- Deng, Qiaolin (author)
- Karolinska Institutet,Karolinska Institute
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- Giselsson, Pontus (author)
- Lund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: AI och digitalisering,LTH profilområden,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: AI and Digitalization,LTH Profile areas,Faculty of Engineering, LTH
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- Genander, Maria (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Developmental Cell. - 1534-5807 .- 1878-1551. ; 59:10, s. 6-1283
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Abstract
Subject headings
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- Progenitor cells adapt their behavior in response to tissue demands. However, the molecular mechanisms controlling esophageal progenitor decisions remain largely unknown. Here, we demonstrate the presence of a Troy (Tnfrsf19)-expressing progenitor subpopulation localized to defined regions along the mouse esophageal axis. Lineage tracing and mathematical modeling demonstrate that Troy-positive progenitor cells are prone to undergoing symmetrical fate choices and contribute to esophageal tissue homeostasis long term. Functionally, TROY inhibits progenitor proliferation and enables commitment to differentiation without affecting fate symmetry. Whereas Troy expression is stable during esophageal homeostasis, progenitor cells downregulate Troy in response to tissue stress, enabling proliferative expansion of basal cells refractory to differentiation and reestablishment of tissue homeostasis. Our results demonstrate functional, spatially restricted progenitor heterogeneity in the esophageal epithelium and identify how dynamic regulation of Troy coordinates tissue generation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- differentiation
- esophagus
- fate choice
- progenitor cell
- proliferation
- regeneration
- Troy
Publication and Content Type
- art (subject category)
- ref (subject category)
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