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- Fang, QiThird Affiliated Hospital of Soochow University (author)
Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- Anticancer Research USA Inc.2017
- 8 s.
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- LIBRIS-ID:oai:lup.lub.lu.se:a83849db-449d-4623-9ee1-8676a5eb424d
- https://lup.lub.lu.se/record/a83849db-449d-4623-9ee1-8676a5eb424dURI
- https://doi.org/10.21873/anticanres.11892DOI
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- Language:English
- Summary in:English
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- Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Breast cancer
- CXCL8
- Estrogen receptor
- Overall survival
- Progesterone receptor
Added entries (persons, corporate bodies, meetings, titles ...)
- Wang, XufenThird Affiliated Hospital of Soochow University (author)
- Luo, GuanghuaThird Affiliated Hospital of Soochow University (author)
- Yu, MiaomeiThird Affiliated Hospital of Soochow University (author)
- Zhang, XiaoyingThird Affiliated Hospital of Soochow University (author)
- Xu, NingLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-nxu (author)
- Third Affiliated Hospital of Soochow UniversityAvdelningen för klinisk kemi och farmakologi (creator_code:org_t)
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- In:Anticancer research: Anticancer Research USA Inc.37:9, s. 4845-48520250-70051791-7530
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- MEDICAL AND HEALTH SCIENCES
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