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Increased CXCL8 exp...
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Fang, QiThird Affiliated Hospital of Soochow University
(author)
Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Anticancer Research USA Inc.2017
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8 s.
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LIBRIS-ID:oai:lup.lub.lu.se:a83849db-449d-4623-9ee1-8676a5eb424d
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https://lup.lub.lu.se/record/a83849db-449d-4623-9ee1-8676a5eb424dURI
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https://doi.org/10.21873/anticanres.11892DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.
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Wang, XufenThird Affiliated Hospital of Soochow University
(author)
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Luo, GuanghuaThird Affiliated Hospital of Soochow University
(author)
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Yu, MiaomeiThird Affiliated Hospital of Soochow University
(author)
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Zhang, XiaoyingThird Affiliated Hospital of Soochow University
(author)
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Xu, NingLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-nxu
(author)
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Third Affiliated Hospital of Soochow UniversityAvdelningen för klinisk kemi och farmakologi
(creator_code:org_t)
Related titles
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In:Anticancer research: Anticancer Research USA Inc.37:9, s. 4845-48520250-70051791-7530
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