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Interval breast can...
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Ugalde-Morales, EmilioKarolinska Institutet,Karolinska Institute
(author)
Interval breast cancer is associated with interferon immune response
- Article/chapterEnglish2022
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LIBRIS-ID:oai:lup.lub.lu.se:a8416386-ad1a-470a-87dc-aa039af2033a
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https://lup.lub.lu.se/record/a8416386-ad1a-470a-87dc-aa039af2033aURI
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https://doi.org/10.1016/j.ejca.2021.12.003DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149687968URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: The aggressive nature of breast cancers detected between planned mammographic screens, so-called interval cancers, remains elusive. Here, we aim to characterise underlying molecular features of interval cancer. Methods: From 672 patients with invasive breast cancer, we analysed gene expression differences between 90 ‘true’ interval cancer cases (i.e. women with low-dense breasts defined as per cent mammographic density <25%) and 310 screen-detected tumours while accounting for PAM50 subtypes and thus overall tumour aggressiveness. We computed an interval cancer gene expression profile (IC-Gx) in a total of 2270 breast tumours (regardless of interval cancer status) and tested for association with expression-based immune subtypes in breast cancer. In addition, we investigated the contribution of inherited and somatic genetic variants in distinct features of interval cancer. Results: We identified 8331 genes nominally associated with interval cancer (P-value < 0.05, fold-change > 1.5). Gene set enrichment analysis showed immune-related pathways as key processes altered in interval cancer. Our IC-Gx, based on 47 genes with the strongest associations (false discovery rate < 0.05), was found to be associated mainly with immune subtypes involving interferon response. We isolated an interaction network of interval cancer and interferon genes for which a significant load of somatic and germline variants in class I interferon genes was observed. Conclusion: We identified novel molecular features of interval breast cancer highlighting interferon pathways as a potential target for prevention or treatment.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Grassmann, FelixKarolinska Institutet,Karolinska Institute,Health and Medical University
(author)
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Humphreys, KeithKarolinska Institutet,Karolinska Institute(Swepub:lu)med-khu
(author)
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Li, JingmeiKarolinska Institute,National University of Singapore,A*Star, Genome Institute of Singapore (GIS)
(author)
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Eriksson, MikaelKarolinska Institutet,Karolinska Institute
(author)
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Tobin, Nicholas P.Karolinska Institutet,Karolinska Institute(Swepub:lu)med-npt
(author)
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Lindström, Linda S.Karolinska Institutet,Karolinska Institute
(author)
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Vallon-Christersson, JohanLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-jvc
(author)
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Borg, ÅkeLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo
(author)
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Hall, PerKarolinska Institutet,Karolinska Institute
(author)
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Czene, KamilaKarolinska Institutet,Karolinska Institute
(author)
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Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
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In:European Journal of Cancer: Elsevier BV162, s. 194-2050959-80491879-0852
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Ugalde-Morales, ...
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Grassmann, Felix
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Humphreys, Keith
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Li, Jingmei
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Eriksson, Mikael
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Tobin, Nicholas ...
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Lindström, Linda ...
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Vallon-Christers ...
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Borg, Åke
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Hall, Per
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Czene, Kamila
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