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Reservoir Pressure ...
Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults
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- Aizawa, Kunihiko (author)
- University of Exeter
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- Hughes, Alun D. (author)
- University College London
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- Casanova, Francesco (author)
- University of Exeter
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- Gates, Phillip E. (author)
- University of Exeter
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- Mawson, David M. (author)
- University of Exeter
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- Gooding, Kim M. (author)
- University of Exeter
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- Gilchrist, Mark (author)
- University of Exeter
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- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups
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- Khan, Faisel (author)
- University of Dundee
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- Colhoun, Helen M. (author)
- University of Edinburgh
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- Palombo, Carlo (author)
- University of Pisa
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- Parker, Kim H. (author)
- Imperial College London
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- Shore, Angela C. (author)
- University of Exeter
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(creator_code:org_t)
- 2022
- 2022
- English 9 s.
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In: Hypertension. - 0194-911X. ; 79:10, s. 2364-2372
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years. Methods: Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry. Results: After 3 years, and in a group of 94 individuals (72.4±7.6 years, 26 females), there was an estimated glomerular filtration rate reduction of >5% per year (median reduction of 20.5% over 3 years). A multivariable logistic regression analysis revealed that higher baseline reservoir pressure integral was independently associated with a smaller reduction in estimated glomerular filtration rate after accounting for conventional cardiovascular risk factors and study centers (odds ratio: 0.660 [95% CIs, 0.494-0.883]; P=0.005). The association remained unchanged after further adjustments for potential confounders and baseline renal function (odds ratio: 0.528 [95% CIs, 0.351-0.794]; P=0.002). No other reservoir-excess pressure parameters exhibited associations with the reduction in renal function. Conclusions: This study demonstrates that baseline reservoir pressure integral was associated with the decline in renal function in older adults at 3-year follow-up, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Aging
- Blood pressure
- Hemodynamics
- Kidney
- Risk factors
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Aizawa, Kunihiko
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Hughes, Alun D.
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Casanova, France ...
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Gates, Phillip E ...
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Mawson, David M.
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Gooding, Kim M.
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show more...
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Gilchrist, Mark
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Goncalves, Isabe ...
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Nilsson, Jan
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Khan, Faisel
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Colhoun, Helen M ...
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Palombo, Carlo
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Parker, Kim H.
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Shore, Angela C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Hypertension
- By the university
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Lund University