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Diagnostic and prog...
Diagnostic and prognostic factors in patients with prostate cancer : a systematic review
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- Beyer, Katharina (author)
- King's College London
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- Moris, Lisa (author)
- University Hospitals Leuven
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- Lardas, Michael (author)
- Metropolitan Hospital
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Haire, Anna (author)
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- Barletta, Francesco (author)
- San Raffaele Hospital
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- Scuderi, Simone (author)
- San Raffaele Hospital
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- Molnar, Megan (author)
- Bayer Pharma AG
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- Herrera, Ronald (author)
- Bayer Pharma AG
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Rauf, Abdul (author)
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- Campi, Riccardo (author)
- University of Florence
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- Greco, Isabella (author)
- University of Florence
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Shiranov, Kirill (author)
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- Dabestani, Saeed (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Central Hospital Kristianstad
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- Van Den Broeck, Thomas (author)
- University Hospitals Leuven
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Arun, Sujenthiran (author)
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- Gacci, Mauro (author)
- University of Florence
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- Gandaglia, Giorgio (author)
- San Raffaele Hospital
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- Omar, Muhammad Imran (author)
- University of Aberdeen
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- MacLennan, Steven (author)
- University of Aberdeen
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- Roobol, Monique J. (author)
- Erasmus University Medical Center
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- Farahmand, Bahman (author)
- Bayer Pharma AG
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- Vradi, Eleni (author)
- Bayer Pharma AG
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- Devecseri, Zsuzsanna (author)
- Sanofi S.A., France
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- Asiimwe, Alex (author)
- Bayer Pharma AG
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Zong, Jihong (author)
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- MacLennan, Sara J. (author)
- University of Aberdeen
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- Collette, Laurence (author)
- European Organisation for Research and Treatment of Cancer
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- Ndow, James (author)
- Erasmus University Medical Center
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- Briganti, Alberto (author)
- Vita-Salute San Raffaele University,San Raffaele Hospital
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- Bjartell, Anders (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Van Hemelrijck, Mieke (author)
- King's College London
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(creator_code:org_t)
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- 2022-04-04
- 2022
- English.
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In: BMJ Open. - : BMJ. - 2044-6055. ; 12:4
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objectives As part of the PIONEER Consortium objectives, we have explored which diagnostic and prognostic factors (DPFs) are available in relation to our previously defined clinician and patient-reported outcomes for prostate cancer (PCa). Design We performed a systematic review to identify validated and non-validated studies. Data sources MEDLINE, Embase and the Cochrane Library were searched on 21 January 2020. Eligibility criteria Only quantitative studies were included. Single studies with fewer than 50 participants, published before 2014 and looking at outcomes which are not prioritised in the PIONEER core outcome set were excluded. Data extraction and synthesis After initial screening, we extracted data following the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of prognostic factor studies (CHARMS-PF) criteria and discussed the identified factors with a multidisciplinary expert group. The quality of the included papers was scored for applicability and risk of bias using validated tools such as PROBAST, Quality in Prognostic Studies and Quality Assessment of Diagnostic Accuracy Studies 2. Results The search identified 6604 studies, from which 489 DPFs were included. Sixty-four of those were internally or externally validated. However, only three studies on diagnostic and seven studies on prognostic factors had a low risk of bias and a low risk concerning applicability. Conclusion Most of the DPFs identified require additional evaluation and validation in properly designed studies before they can be recommended for use in clinical practice. The PIONEER online search tool for DPFs for PCa will enable researchers to understand the quality of the current research and help them design future studies. Ethics and dissemination There are no ethical implications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- epidemiology
- prostate disease
- urological tumours
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BMJ Open
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- By the author/editor
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Beyer, Katharina
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Moris, Lisa
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Lardas, Michael
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Haire, Anna
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Barletta, France ...
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Scuderi, Simone
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show more...
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Molnar, Megan
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Herrera, Ronald
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Rauf, Abdul
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Campi, Riccardo
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Greco, Isabella
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Shiranov, Kirill
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Dabestani, Saeed
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Van Den Broeck, ...
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Arun, Sujenthira ...
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Gacci, Mauro
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Gandaglia, Giorg ...
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Omar, Muhammad I ...
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MacLennan, Steve ...
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Roobol, Monique ...
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Farahmand, Bahma ...
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Vradi, Eleni
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Devecseri, Zsuzs ...
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Asiimwe, Alex
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Zong, Jihong
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MacLennan, Sara ...
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Collette, Lauren ...
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Ndow, James
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Briganti, Albert ...
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Bjartell, Anders
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Van Hemelrijck, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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BMJ Open
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Lund University