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Diagnostic and prog...
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Beyer, KatharinaKing's College London
(author)
Diagnostic and prognostic factors in patients with prostate cancer : a systematic review
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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LIBRIS-ID:oai:lup.lub.lu.se:a96e3385-6bd4-4f19-8cec-d03645564a6b
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https://lup.lub.lu.se/record/a96e3385-6bd4-4f19-8cec-d03645564a6bURI
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https://doi.org/10.1136/bmjopen-2021-058267DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
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Objectives As part of the PIONEER Consortium objectives, we have explored which diagnostic and prognostic factors (DPFs) are available in relation to our previously defined clinician and patient-reported outcomes for prostate cancer (PCa). Design We performed a systematic review to identify validated and non-validated studies. Data sources MEDLINE, Embase and the Cochrane Library were searched on 21 January 2020. Eligibility criteria Only quantitative studies were included. Single studies with fewer than 50 participants, published before 2014 and looking at outcomes which are not prioritised in the PIONEER core outcome set were excluded. Data extraction and synthesis After initial screening, we extracted data following the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of prognostic factor studies (CHARMS-PF) criteria and discussed the identified factors with a multidisciplinary expert group. The quality of the included papers was scored for applicability and risk of bias using validated tools such as PROBAST, Quality in Prognostic Studies and Quality Assessment of Diagnostic Accuracy Studies 2. Results The search identified 6604 studies, from which 489 DPFs were included. Sixty-four of those were internally or externally validated. However, only three studies on diagnostic and seven studies on prognostic factors had a low risk of bias and a low risk concerning applicability. Conclusion Most of the DPFs identified require additional evaluation and validation in properly designed studies before they can be recommended for use in clinical practice. The PIONEER online search tool for DPFs for PCa will enable researchers to understand the quality of the current research and help them design future studies. Ethics and dissemination There are no ethical implications.
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Moris, LisaUniversity Hospitals Leuven
(author)
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Lardas, MichaelMetropolitan Hospital
(author)
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Haire, Anna
(author)
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Barletta, FrancescoSan Raffaele Hospital
(author)
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Scuderi, SimoneSan Raffaele Hospital
(author)
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Molnar, MeganBayer Pharma AG
(author)
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Herrera, RonaldBayer Pharma AG
(author)
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Rauf, Abdul
(author)
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Campi, RiccardoUniversity of Florence
(author)
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Greco, IsabellaUniversity of Florence
(author)
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Shiranov, Kirill
(author)
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Dabestani, SaeedLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Central Hospital Kristianstad(Swepub:lu)med-sdd
(author)
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Van Den Broeck, ThomasUniversity Hospitals Leuven
(author)
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Arun, Sujenthiran
(author)
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Gacci, MauroUniversity of Florence
(author)
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Gandaglia, GiorgioSan Raffaele Hospital
(author)
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Omar, Muhammad ImranUniversity of Aberdeen
(author)
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MacLennan, StevenUniversity of Aberdeen
(author)
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Roobol, Monique J.Erasmus University Medical Center
(author)
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Farahmand, BahmanBayer Pharma AG
(author)
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Vradi, EleniBayer Pharma AG
(author)
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Devecseri, ZsuzsannaSanofi S.A., France
(author)
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Asiimwe, AlexBayer Pharma AG
(author)
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Zong, Jihong
(author)
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MacLennan, Sara J.University of Aberdeen
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Collette, LaurenceEuropean Organisation for Research and Treatment of Cancer
(author)
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Ndow, JamesErasmus University Medical Center
(author)
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Briganti, AlbertoSan Raffaele Hospital,Vita-Salute San Raffaele University
(author)
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Bjartell, AndersLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)kir-abj
(author)
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Van Hemelrijck, MiekeKing's College London
(author)
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King's College LondonUniversity Hospitals Leuven
(creator_code:org_t)
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The PIONEER Consortium
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In:BMJ Open: BMJ12:42044-6055
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Beyer, Katharina
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Moris, Lisa
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Lardas, Michael
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Barletta, France ...
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Scuderi, Simone
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Molnar, Megan
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Herrera, Ronald
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Rauf, Abdul
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Campi, Riccardo
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Greco, Isabella
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Shiranov, Kirill
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Dabestani, Saeed
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Van Den Broeck, ...
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Arun, Sujenthira ...
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Gacci, Mauro
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Farahmand, Bahma ...
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Vradi, Eleni
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