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Insulin resistance and its relationship with long-term exposure to ozone : Data based on a national population cohort

Zhang, Zenglei (author)
Fu Wai Hospital
Luan, Cheng (author)
Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
Wang, Chunqi (author)
Fu Wai Hospital
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Li, Tiantian (author)
Chinese Center for Disease Control and Prevention
Wu, Yi (author)
Fu Wai Hospital
Huang, Xin (author)
Fu Wai Hospital
Jin, Bolin (author)
Fu Wai Hospital
Zhang, Enming (author)
Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Diabetes - Islet Patophysiology,Lund University Research Groups,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas
Gong, Qiuhong (author)
Fu Wai Hospital
Zhou, Xianliang (author)
Fu Wai Hospital
Li, Xi (author)
Fu Wai Hospital
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 (creator_code:org_t)
2024
2024
English.
In: Journal of Hazardous Materials. - 0304-3894. ; 472
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The relationship of ozone (O3), particularly the long-term exposure, with impacting metabolic homeostasis in population was understudied and under-recognised. Here, we used data from ChinaHEART, a nationwide, population-based cohort study, combined with O3 and PM2.5 concentration data with high spatiotemporal resolution, to explore the independent association of exposure to O3 with the prevalence of insulin resistance (IR). Among the 271 540 participants included, the crude prevalence of IR was 39.1%, while the age and sex standardized prevalence stood at 33.0%. Higher IR prevalence was observed with each increase of 10.0 μg/m3 in long-term O3 exposure, yielding adjusted odds ratios (OR) of 1.084 (95% CI: 1.079–1.089) in the one-pollutant model and 1.073 (95% CI: 1.067–1.079) in the two-pollutant model. Notably, a significant additive interaction between O3 and PM2.5 on the prevalence of IR was observed (P for additive interaction < 0.001). Our main findings remained consistent and robust in the sensitivity analyses. Our study suggests long-term exposure to O3 was independently and positively associated with prevalence of IR. It emphasized the benefits of policy interventions to reduce O3 and PM2.5 exposure jointly, which could ultimately alleviate the health and economic burden related to DM.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Airborne pollutants
Estimated glucose disposal rate
Insulin resistance
Long-term exposure
Ozone

Publication and Content Type

art (subject category)
ref (subject category)

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