SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:aa038b7b-07d0-42cc-830a-d266785bec48"
 

Search: onr:"swepub:oai:lup.lub.lu.se:aa038b7b-07d0-42cc-830a-d266785bec48" > A large-scale genet...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Krüger, RejkoUniversity of Tübingen (author)

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Elsevier BV,2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:aa038b7b-07d0-42cc-830a-d266785bec48
  • https://lup.lub.lu.se/record/aa038b7b-07d0-42cc-830a-d266785bec48URI
  • https://doi.org/10.1016/j.neurobiolaging.2009.11.021DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122486956URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common Omi/HtrA2 variants in the Genetic Epidemiology of Parkinson's disease (GEO-PD) consortium. GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the Omi/HtrA2 gene in approximately 2-3 kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of Omi/HtrA2 variants. The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five Omi/HtrA2 SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant Q statistics for all 5 SNPs; I(2) estimates 0-28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, p=0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, p=0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest. This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sharma, ManuUniversity of Tübingen (author)
  • Riess, OlafUniversity of Tübingen (author)
  • Gasser, ThomasUniversity of Tübingen (author)
  • Van Broeckhoven, ChristineUniversity of Antwerp (author)
  • Theuns, JessieUniversity of Antwerp (author)
  • Aasly, JanNorwegian University of Science and Technology (author)
  • Annesi, GraziaCNR: National Research Council of Italy (author)
  • Bentivoglio, Anna RitaCatholic University of the Sacred Heart, Rome (author)
  • Brice, AlexisParis-Sorbonne University (author)
  • Djarmati, Ana (author)
  • Elbaz, Alexis (author)
  • Farrer, Matthew (author)
  • Ferrarese, Carlo (author)
  • Gibson, J. Mark (author)
  • Hadjigeorgiou, Georgios M. (author)
  • Hattori, Nobutaka (author)
  • Ioannidis, John P A (author)
  • Jasinska-Myga, Barbara (author)
  • Klein, Christine (author)
  • Lambert, Jean-Charles (author)
  • Lesage, Suzanne (author)
  • Lin, Juei-Jueng (author)
  • Lynch, Timothy (author)
  • Mellick, George D. (author)
  • de Nigris, Francesa (author)
  • Opala, Grzegorz (author)
  • Prigione, Alessandro (author)
  • Quattrone, Aldo (author)
  • Ross, Owen A. (author)
  • Satake, Wataru (author)
  • Silburn, Peter A. (author)
  • Tan, Eng-King (author)
  • Toda, Tatsushi (author)
  • Tomiyama, Hiroyuki (author)
  • Wirdefeldt, KarinKarolinska Institutet (author)
  • Wszolek, Zbigniew K (author)
  • Xiromerisiou, Georgia (author)
  • Maraganore, Demetrius M. (author)
  • Puschmann, AndreasLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-aps (author)
  • University of TübingenUniversity of Antwerp (creator_code:org_t)
  • Genetic Epidemiology of Parkinson's disease consortium

Related titles

  • In:Neurobiology of Aging: Elsevier BV32:3, s. 9-5481558-14970197-4580

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view