The adult human brain harbors multipotent perivascular mesenchymal stem cells.

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The adult human brain harbors multipotent perivascular mesenchymal stem cells.

Paul-Visse, Gesine (author): Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Department of Experimental Medical Science,Faculty of Medicine,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund

Ozen, Ilknur (author): Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Department of Experimental Medical Science,Faculty of Medicine,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund

Christophersen, Nicolaj (author)

Reinbothe, Thomas (author): Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups

Bengzon, Johan (author): Lund University,Lunds universitet,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine

Visse, Edward (author): Lund University,Lunds universitet,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine

Jansson, Katarina (author)

Dannaeus, Karin (author)

Henriques-Oliveira, Catarina (author)

Roybon, Laurent (author): Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine

Anisimov, Sergey (author)

Renström, Erik (author): Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups

Svensson, Mikael (author): Karolinska Institutet

Haegerstrand, Anders (author)

Brundin, Patrik (author)

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2012-04-16
2012
English.
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:4

Related links:: https://portal.resea... (primary) (free); show more...; http://www.ncbi.nlm.... (free); http://dx.doi.org/10... (free); https://journals.plo...; https://lup.lub.lu.s...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this perivascular niche, a stem cell with mesenchymal characteristics was recently identified in some adult somatic tissues. These cells are pericytes that line the microvasculature, express mesenchymal markers and differentiate into mesodermal lineages but might even have the capacity to generate tissue-specific cell types. Here, we isolated, purified and characterized a previously unrecognized progenitor population from two different regions in the adult human brain, the ventricular wall and the neocortex. We show that these cells co-express markers for mesenchymal stem cells and pericytes in vivo and in vitro, but do not express glial, neuronal progenitor, hematopoietic, endothelial or microglial markers in their native state. Furthermore, we demonstrate at a clonal level that these progenitors have true multilineage potential towards both, the mesodermal and neuroectodermal phenotype. They can be epigenetically induced in vitro into adipocytes, chondroblasts and osteoblasts but also into glial cells and immature neurons. This progenitor population exhibits long-term proliferation, karyotype stability and retention of phenotype and multipotency following extensive propagation. Thus, we provide evidence that the vascular niche in the adult human brain harbors a novel progenitor with multilineage capacity that appears to represent mesenchymal stem cells and is different from any previously described human neural stem cell. Future studies will elucidate whether these cells may play a role for disease or may represent a reservoir that can be exploited in efforts to repair the diseased human brain.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

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By the author/editor: Paul-Visse, Gesi ...; Ozen, Ilknur; Christophersen, ...; Reinbothe, Thoma ...; Bengzon, Johan; Visse, Edward; show more...; Jansson, Katarin ...; Dannaeus, Karin; Henriques-Olivei ...; Roybon, Laurent; Anisimov, Sergey; Renström, Erik; Svensson, Mikael; Haegerstrand, An ...; Brundin, Patrik; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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By the university: Lund University; Karolinska Institutet

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