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  • Ali, Syed Raza (author)

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-05-05
  • Rockefeller University Press,2014
  • electronicrdacarrier

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  • LIBRIS-ID:oai:lup.lub.lu.se:aaa06cf1-c47c-4673-9ad9-5bfc65e85ba9
  • https://lup.lub.lu.se/record/4609589URI
  • https://doi.org/10.1084/jem.20131853DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Group B Streptococcus (GBS) causes invasive infections in human newborns. We recently showed that the GBS beta-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes. Interestingly, neutrophils and monocytes also express Siglec-14, which has a ligand-binding domain almost identical to Siglec-5 but signals via an activating motif, raising the possibility that these are paired Siglec receptors that balance immune responses to pathogens. Here we show that beta-protein-expressing GBS binds to both Siglec-5 and Siglec-14 on neutrophils and that the latter engagement counteracts pathogen-induced host immune suppression by activating p38 mitogen-activated protein kinase (MAPK) and AKT signaling pathways. Siglec-14 is absent from some humans because of a SIGLEC14-null polymorphism, and homozygous SIGLEC14-null neutrophils are more susceptible to GBS immune subversion. Finally, we report an unexpected human-specific expression of Siglec-5 and Siglec-14 on amniotic epithelium, the site of initial contact of invading GBS with the fetus. GBS amnion immune activation was likewise influenced by the SIGLEC14-null polymorphism. We provide initial evidence that the polymorphism could influence the risk of prematurity among human fetuses of mothers colonized with GBS. This first functionally proven example of a paired receptor system in the Siglec family has multiple implications for regulation of host immunity.

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  • Fong, Jerry J. (author)
  • Carlin, Aaron F. (author)
  • Busch, Tamara D. (author)
  • Linden, Rebecka (author)
  • Angata, Takashi (author)
  • Areschoug, ThomasLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-tar (author)
  • Parast, Mana (author)
  • Varki, Nissi (author)
  • Murray, Jeffrey (author)
  • Nizet, Victor (author)
  • Varki, Ajit (author)
  • Avdelningen för medicinsk mikrobiologiInstitutionen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:Journal of Experimental Medicine: Rockefeller University Press211:6, s. 1231-12421540-95380022-1007

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