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Pituitary adenylate...
Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation
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- Zhang, Y (author)
- Lund University
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- Danielsen, N (author)
- Lund University,Lunds universitet,Neurala gränsytor,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Neural Interfaces,Lund University Research Groups
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- Sundler, F (author)
- Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups
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- Mulder, H (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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(creator_code:org_t)
- 1998
- 1998
- English 4 s.
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In: NeuroReport. - 0959-4965. ; 9:12, s. 2833-2836
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
Close
- The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced inflammation in the rat paw. At 12 h and day 3, but not day 21, the percentage of neurons expressing PACAP mRNA was greater in the innervating L5 DRG. Similarly, PACAP mRNA expression in individual neurons was higher in the innervating L5 DRG at 12 h and day 3, but not day 21. Up-regulated PACAP expression following adjuvant injection suggests a role for PACAP in inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Animals
- Female
- Freund's Adjuvant
- Ganglia, Spinal
- In Situ Hybridization
- Inflammation
- Neurons, Afferent
- Neuropeptides
- Pituitary Adenylate Cyclase-Activating Polypeptide
- RNA, Messenger
- Rats
- Rats, Sprague-Dawley
- Up-Regulation
- Journal Article
- Research Support, Non-U.S. Gov't
Publication and Content Type
- art (subject category)
- ref (subject category)
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