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Prospects for impro...
Prospects for improved glomerular filtration rate estimation based on creatinine—results from a transnational multicentre study
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- Björk, Jonas (author)
- Lund University,Lunds universitet,Centrum för ekonomisk demografi,Ekonomihögskolan,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Kirurgi och folkhälsa,Forskargrupper vid Lunds universitet,EPI@LUND,Centre for Economic Demography,Lund University School of Economics and Management, LUSEM,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Surgery and public health,Lund University Research Groups
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- Nyman, Ulf (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Courbebaisse, Marie (author)
- Paris Descartes University
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- Couzi, Lionel (author)
- University of Bordeaux
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- Dalton, R Neil (author)
- Evelina London Children's Healthcare
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- Dubourg, Laurence (author)
- Hôpital Edouard Herriot
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- Ebert, Natalie (author)
- Charité - University Medicine Berlin
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- Eriksen, Bjørn Odvar (author)
- UiT The Arctic University of Norway, Tromsø
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- Gaillard, Francois (author)
- Assistance Publique des Hôpitaux de Paris
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- Garrouste, Cyril (author)
- Clermont-Ferrand University Hospital
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- Grubb, Anders (author)
- Lund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups
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- Hansson, Magnus (author)
- Karolinska Institutet
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- Jacquemont, Lola (author)
- University of Nantes
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- Jones, Ian (author)
- Örebro University,Örebro University Hospital
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- Kamar, Nassim (author)
- Université Paul Sabatier
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- Lamb, Edmund J. (author)
- Great Ormond Street Hospital
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- Legendre, Christophe (author)
- Paris Descartes University
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- Littmann, Karin (author)
- Karolinska Institutet
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- Mariat, Christophe (author)
- Hopital Nord CHU de Sainte-Etienne
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- Melsom, Toralf (author)
- UiT The Arctic University of Norway, Tromsø
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- Rostaing, Lionel (author)
- Grenoble University Hospital
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- Rule, Andrew D. (author)
- Mayo Clinic Minnesota
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- Schaeffner, Elke (author)
- Charité - University Medicine Berlin
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- Sundin, Per-Ola (author)
- Örebro University
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- Turner, Stephen (author)
- Mayo Clinic Minnesota
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- Åkesson, Anna (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Kliniska Studier Sverige, Forum söder
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- Delanaye, Pierre (author)
- University of Liège Hospital,University of Liège
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- Pottel, Hans (author)
- Catholic University of Leuven
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(creator_code:org_t)
- 2020-06-13
- 2020
- English 10 s.
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In: Clinical Kidney Journal. - : Oxford University Press (OUP). - 2048-8505 .- 2048-8513. ; 13:4, s. 674-683
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Abstract
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- Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.MethodsIn a cross-sectional analysis covering the years 2003–17, CKD-EPI was validated against measured GFR (mGFR; using various tracer methods) in patients with high likelihood of chronic kidney disease (CKD; five CKD cohorts, n = 8365) and in patients with low likelihood of CKD (six community cohorts, n = 6759). Comparisons were made with the Lund–Malmö revised equation (LMR) and the Full Age Spectrum equation.Results7In patients aged 18–39 years old, CKD-EPI overestimated GFR with 5.0–16 mL/min/1.73 m2 in median in both cohort types at mGFR levels <120 mL/min/1.73 m2. LMR had greater accuracy than CKD-EPI in the CKD cohorts (P30, the percentage of estimated GFR within 30% of mGFR, 83.5% versus 76.6%). CKD-EPI was generally the most accurate equation in the community cohorts, but all three equations reached P30 above the Kidney Disease Outcomes Quality Initiative benchmark of 90%.ConclusionsNone of the evaluated equations made optimal use of available data. Prospects for improved GFR estimation procedures based on creatinine exist, particularly in young adults and in settings where patients with suspected or manifest CKD are investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Björk, Jonas
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Nyman, Ulf
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Courbebaisse, Ma ...
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Couzi, Lionel
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Dalton, R Neil
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Dubourg, Laurenc ...
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show more...
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Ebert, Natalie
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Eriksen, Bjørn O ...
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Gaillard, Franco ...
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Garrouste, Cyril
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Grubb, Anders
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Hansson, Magnus
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Jacquemont, Lola
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Jones, Ian
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Kamar, Nassim
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Lamb, Edmund J.
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Legendre, Christ ...
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Littmann, Karin
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Mariat, Christop ...
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Melsom, Toralf
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Rostaing, Lionel
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Rule, Andrew D.
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Schaeffner, Elke
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Sundin, Per-Ola
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Turner, Stephen
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Åkesson, Anna
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Delanaye, Pierre
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Pottel, Hans
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Clinical Kidney ...
- By the university
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Lund University
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Karolinska Institutet