Search: onr:"swepub:oai:lup.lub.lu.se:ab62fec5-4647-4e40-9c36-2775254be19e" > Human papillomaviru...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07516naa a2200913 4500 | |
001 | oai:lup.lub.lu.se:ab62fec5-4647-4e40-9c36-2775254be19e | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-20694 | |
009 | oai:prod.swepub.kib.ki.se:115974015 | |
009 | oai:gup.ub.gu.se/58590 | |
009 | oai:DiVA.org:uu-143335 | |
024 | 7 | a https://lup.lub.lu.se/record/6085082 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206942 URI |
024 | 7 | a https://doi.org/10.1056/NEJMoa0732042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1159740152 URI |
024 | 7 | a https://gup.ub.gu.se/publication/585902 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1433352 URI |
040 | a (SwePub)lud (SwePub)umud (SwePub)kid (SwePub)gud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Naucler, Pontusu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-pun |
245 | 1 0 | a Human papillomavirus and Papanicolaou tests to screen for cervical cancer. |
264 | 1 | a Boston, Massachusetts :b Massachusetts medical society,c 2007 |
520 | a Background Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or cervical cancer is unknown. Methods In a population-based screening program in Sweden, 12,527 women 32 to 38 years of age were randomly assigned at a 1:1 ratio to have an HPV test plus a Papanicolaou (Pap) test (intervention group) or a Pap test alone (control group). Women with a positive HPV test and a normal Pap test result were offered a second HPV test at least 1 year later, and those who were found to be persistently infected with the same high-risk type of HPV were then offered colposcopy with cervical biopsy. A similar number of double-blinded Pap smears and colposcopies with biopsy were performed in randomly selected women in the control group. Comprehensive registry data were used to follow the women for a mean of 4.1 years. The relative rates of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected at enrollment and at subsequent screening examinations were calculated. Results At enrollment, the proportion of women in the intervention group who were found to have lesions of grade 2 or 3 cervical intraepithelial neoplasia or cancer was 51% greater (95% confidence interval [CI], 13 to 102) than the proportion of women in the control group who were found to have such lesions. At subsequent screening examinations, the proportion of women in the intervention group who were found to have grade 2 or 3 lesions or cancer was 42% less (95% CI, 4 to 64) and the proportion with grade 3 lesions or cancer was 47% less (95% CI, 2 to 71) than the proportions of control women who were found to have such lesions. Women with persistent HPV infection remained at high risk for grade 2 or 3 lesions or cancer after referral for colposcopy. Conclusions The addition of an HPV test to the Pap test to screen women in their mid-30s for cervical cancer reduces the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected by subsequent screening examinations. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
653 | a Adult | |
653 | a Cervical Intraepithelial Neoplasia: diagnosis | |
653 | a Cervical Intraepithelial Neoplasia: pathology | |
653 | a Cervical Intraepithelial Neoplasia: prevention & control | |
653 | a DNA | |
653 | a Colposcopy | |
653 | a Sensitivity and Specificity | |
653 | a Polymerase Chain Reaction | |
653 | a Papillomavirus Infections: diagnosis | |
653 | a Papillomaviridae: isolation & purification | |
653 | a Mass Screening | |
653 | a Papillomaviridae: genetics | |
653 | a Vaginal Smears | |
653 | a Viral: analysis | |
653 | a Double-Blind Method | |
653 | a Female | |
653 | a Humans | |
653 | a Uterine Cervical Neoplasms: diagnosis | |
653 | a Uterine Cervical Neoplasms: prevention & control | |
653 | a Uterine Cervical Neoplasms: pathology | |
653 | a | |
653 | a control | |
653 | a Viral/*analysis | |
653 | a Papillomaviridae/genetics/*isolation & purification | |
653 | a Papillomavirus Infections/*diagnosis | |
653 | a Uterine Cervical Neoplasms/*diagnosis/pathology/prevention & control | |
653 | a *Vaginal Smears | |
653 | a MEDICINE | |
700 | 1 | a Ryd, Walteru Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology4 aut |
700 | 1 | a Tornberg, Svenu Karolinska Institutet4 aut |
700 | 1 | a Strand, Andersu Uppsala universitet,Dermatologi och venereologi4 aut0 (Swepub:uu)andestra |
700 | 1 | a Wadell, Göranu Umeå universitet,Virologi4 aut0 (Swepub:umu)gowa0001 |
700 | 1 | a Elfgren, Kristina4 aut |
700 | 1 | a Radberg, Thomasu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut |
700 | 1 | a Strander, Björn,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xstrbj |
700 | 1 | a Forslund, Olau Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-ofo |
700 | 1 | a Hansson, Bengt-Göranu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-bha |
700 | 1 | a Rylander, Evau Karolinska Institutet4 aut |
700 | 1 | a Dillner, Joakimu Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi |
700 | 1 | a Johansson, Bo4 aut |
710 | 2 | a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t New England Journal of Medicined Boston, Massachusetts : Massachusetts medical societyg 357:16, s. 1589-97q 357:16<1589-1597x 0028-4793x 1533-4406 |
773 | 0 | t N Engl J Medd Boston, Massachusetts : Massachusetts medical societyg 357:16, s. 1589-97q 357:16<1589-97 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17942872&dopt=Abstracty FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/608508 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-20694 |
856 | 4 8 | u https://doi.org/10.1056/NEJMoa073204 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115974015 |
856 | 4 8 | u https://gup.ub.gu.se/publication/58590 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-143335 |
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