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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
- Horikawa, Y (author)
- Oda, N (author)
- Cox, N J (author)
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- Li, X (author)
- Hara, M (author)
- Hinokio, Y (author)
- Lindner, T H (author)
- Mashima, H (author)
- Schwarz, P E (author)
- del Bosque-Plata, L (author)
- Horikawa, Y (author)
- Oda, Y (author)
- Yoshiuchi, I (author)
- Colilla, S (author)
- Polonsky, K S (author)
- Wei, S (author)
- Concannon, P (author)
- Iwasaki, N (author)
- Schulze, J (author)
- Baier, Leslie J. (author)
- Bogardus, Clifton (author)
- Boerwinkle, Eric (author)
- Hanis, Craig L. (author)
- Bell, Graeme I. (author)
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 2000
- 2000
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 26:2, s. 163-175
- Journal article (peer-reviewed)
Abstract
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- Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Horikawa, Y
- Oda, N
- Cox, N J
- Li, X
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- Hara, M
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- Hinokio, Y
- Lindner, T H
- Mashima, H
- Schwarz, P E
- del Bosque-Plata ...
- Oda, Y
- Yoshiuchi, I
- Colilla, S
- Polonsky, K S
- Wei, S
- Concannon, P
- Iwasaki, N
- Schulze, J
- Baier, Leslie J.
- Bogardus, Clifto ...
- Groop, Leif
- Boerwinkle, Eric
- Hanis, Craig L.
- Bell, Graeme I.
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