Search: onr:"swepub:oai:lup.lub.lu.se:ae5e5b9a-53ce-4dec-a244-a4330044bf0d" >
Iohexol plasma clea...
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Delanaye, PierreUniversity of Liège Hospital
(author)
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research : A review. Part 2: Why to measure glomerular filtration rate with iohexol?
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-09-09
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Oxford University Press (OUP),2016
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5 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:ae5e5b9a-53ce-4dec-a244-a4330044bf0d
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https://lup.lub.lu.se/record/ae5e5b9a-53ce-4dec-a244-a4330044bf0dURI
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https://doi.org/10.1093/ckj/sfw071DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304089URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrowtherapeutic index. Abnormally elevated GFR or hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies due to GFR estimation with different equations. Using measured GFR, successfully accomplished in large epidemiological studies, is the onlyway to study the potential link between decreased renal function and cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Melsom, ToralfUiT The Arctic University of Norway, Tromsø
(author)
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Ebert, NatalieCharité - University Medicine Berlin
(author)
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Bäck, Sten ErikLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-s-b
(author)
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Mariat, ChristopheJean Monnet University
(author)
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Cavalier, EtienneUniversity of Liège Hospital
(author)
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Björk, JonasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-jbj
(author)
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Christensson, AndersLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ach
(author)
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Nyman, UlfLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-uny
(author)
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Porrini, EstebanUniversity of La Laguna (ULL)
(author)
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Remuzzi, GiuseppeMario Negri Institute for Pharmacological Research
(author)
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Ruggenenti, PieroMario Negri Institute for Pharmacological Research
(author)
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Schaeffner, ElkeCharité - University Medicine Berlin
(author)
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Soveri, Inga,1978-Uppsala universitet,Uppsala University,Njurmedicin,Renal Medicine(Swepub:uu)insov254
(author)
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Sterner, GunnarLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-gst
(author)
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Eriksen, Bjørn OdvarUiT The Arctic University of Norway, Tromsø
(author)
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Gaspari, FlavioMario Negri Institute for Pharmacological Research
(author)
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University of Liège HospitalUiT The Arctic University of Norway, Tromsø
(creator_code:org_t)
Related titles
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In:Clinical Kidney Journal: Oxford University Press (OUP)9:5, s. 700-7042048-85052048-8513
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Delanaye, Pierre
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Melsom, Toralf
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Ebert, Natalie
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Bäck, Sten Erik
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Mariat, Christop ...
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Cavalier, Etienn ...
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Björk, Jonas
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Christensson, An ...
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Nyman, Ulf
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Porrini, Esteban
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Remuzzi, Giusepp ...
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Ruggenenti, Pier ...
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Schaeffner, Elke
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Soveri, Inga, 19 ...
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Sterner, Gunnar
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Eriksen, Bjørn O ...
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Gaspari, Flavio
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