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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03814naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:afad43bf-b129-44b5-8e03-6fbd6b80b3ed | |
| 003 | SwePub | |
| 008 | 220405s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/afad43bf-b129-44b5-8e03-6fbd6b80b3ed2 URI |
| 024 | 7 | a https://doi.org/10.3390/biomedicines100204922 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Bodahl, Sarau Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups4 aut0 (Swepub:lu)sa8501da |
| 245 | 1 0 | a LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling |
| 264 | c 2022-02-19 | |
| 264 | 1 | b MDPI AG,c 2022 |
| 520 | a The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3) expression and signaling, and examine underlying mechanisms. In bronchial epithelial BEAS-2B cells, LL-37 potentiated poly I:C-induced TLR3 mRNA and protein expression demonstrated by qPCR and Western blot, respectively. Interestingly, these effects were associated with increased uptake of rhodamine-tagged poly I:C visualized by immunocytochemistry. The LL-37/poly I:C-induced upregulation of TLR3 mRNA expression was prevented by the endosomal acidification inhibitor chloroquine, indicating involvement of downstream TLR3 signaling. The glucocorticoid dexamethasone reduced LL-37/poly I:C-induced TLR3 expression on both mRNA and protein levels, and this effect was associated with increased IκBα protein expression, suggesting that dexamethasone acts via attenuation of NF-κB activity. We conclude that LL-37 potentiates poly I:C-induced upregulation of TLR3 through a mechanism that may involve enhanced import of poly I:C and that LL-37/poly I:C-induced TLR3 expression is associated with downstream TLR3 signaling and sensitive to inhibition of NF-κB activity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 700 | 1 | a Cerps, Samuelu Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups4 aut0 (Swepub:lu)sa7111ce |
| 700 | 1 | a Uller, Lenau Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-lul |
| 700 | 1 | a Nilsson, Bengt-Olofu Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-bon |
| 710 | 2 | a Kärlfysiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Biomedicinesd : MDPI AGg 10:2q 10:2x 2227-9059 |
| 856 | 4 | u http://dx.doi.org/10.3390/biomedicines10020492x freey FULLTEXT |
| 856 | 4 | u https://www.mdpi.com/2227-9059/10/2/492/pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/afad43bf-b129-44b5-8e03-6fbd6b80b3ed |
| 856 | 4 8 | u https://doi.org/10.3390/biomedicines10020492 |
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