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Effect of everolimu...
Effect of everolimus vs calcineurin inhibitors on quality of life in heart transplant recipients during a 3-year follow-up : Results of a randomized controlled trial (SCHEDULE)
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- Relbo Authen, Anne (author)
- Oslo university hospital,National Hospital Norway, Norway
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- Grov, Ingelin (author)
- Oslo university hospital,National Hospital Norway, Norway
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- Karason, Kristjan (author)
- Sahlgrens University Hospital, Sweden,National Hospital Norway, Norway; University of Oslo, Norway
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- Gustafsson, Finn (author)
- Copenhagen University Hospital,Rigshosp, Denmark
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- Eiskjær, Hans (author)
- Aarhus University Hospital, Denmark
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- Rådegran, Göran (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Lund Hemodynamic Lab,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden;
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- Gude, Einar (author)
- Oslo university hospital,National Hospital Norway, Norway
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- Jansson, Kjell (author)
- Linköpings universitet,Linköping University,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Region Östergötland, Kardiologiska kliniken US
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- Dellgren, Göran (author)
- Sahlgrens University Hospital, Sweden
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- Solbu, Dag (author)
- Novartis Norge AS, Norway
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- Arora, Satish (author)
- National Hospital Norway, Norway; University of Oslo, Norway
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- Andreassen, Arne K. (author)
- Oslo university hospital
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- Gullestad, Lars (author)
- National Hospital Norway, Norway; University of Oslo, Norway
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(creator_code:org_t)
- 2017-07-19
- 2017
- English.
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In: Clinical Transplantation. - : Wiley. - 0902-0063 .- 1399-0012. ; 31:9
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Abstract
Subject headings
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- The Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial was a 12 month, randomized, open-label, parallel-group trial that compared everolimus (EVR; n=56) to conventional CsA (n=59) immunosuppression. Previously, we reported that EVR outperformed CsA in improving renal function and coronary artery vasculopathy, despite a higher rejection rate with EVR. This study aimed to compare the effects of these treatments on quality of life (QoL). Within five post-operative days, patients (mean age 50±13 years, 27% women) were randomized to EVR or a standard CsA dosage (CsA group). This study assessed quality of life (QoL), based on the Short Form-36, EuroQol-5D, and Beck Depression Inventory (BDI). Assessments were performed pre-HTx and 12 and 36 months post-HTx. At 12 and 36 months, the groups showed similar improvements in Short Form-36 measures (at pre-HTx, 12 and 36 months the values were as follows: Physical component summary: EVR: 31.5±110.9, 49.1±9.7, and 47.9±10.6; P<.01; CsA: 32.5±8.2, 48.4±8.5, and 46.5±11.5; P<.01; mental component summary: EVR: 46.0±12.0, 51.7±11.9, and 52.1±13.0; P<.01; CsA: 38.2±12.5, 53.4±7.1, and 54.3±13.0; P<.01); similar decrease in mean BDI (EVR: 10.9±10.2, 5.4±4.7, and 8.1±9.0; P<.01; CsA: 11.8±7.1, 6.3±5.4, and 6.2±6.5; P<.01); and similar Euro Qol-improvements. Thus, in this small-sized study, EVR-based and conventional CsA immunosuppressive strategies produced similar QoL improvements.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Heart transplantation
- Immunosuppression
- Quality of life
- heart transplantation; immunosuppression; quality of life
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Relbo Authen, An ...
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Grov, Ingelin
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Karason, Kristja ...
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Gustafsson, Finn
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Eiskjær, Hans
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Rådegran, Göran
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Gude, Einar
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Jansson, Kjell
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Dellgren, Göran
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Solbu, Dag
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Arora, Satish
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Andreassen, Arne ...
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Gullestad, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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Clinical Transpl ...
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Lund University
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Linköping University