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Treating murine inf...
Treating murine inflammatory diseases with an anti-erythrocyte antibody
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- Crow, Andrew R. (author)
- Saint Michael's Hospital,Toronto Platelet Immunobiology Group,Canadian Blood Services
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- Kapur, Rick (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Canadian Blood Services,University of Amsterdam,Toronto Platelet Immunobiology Group,Saint Michael's Hospital
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- Koernig, Sandra (author)
- University of Melbourne
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- Campbell, Ian K. (author)
- University of Melbourne
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- Jen, Chao Ching (author)
- Saint Michael's Hospital,Toronto Platelet Immunobiology Group
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- Mott, Patrick J. (author)
- Saint Michael's Hospital,Toronto Platelet Immunobiology Group
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- Marjoram, Danielle (author)
- Toronto Platelet Immunobiology Group,Saint Michael's Hospital
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- Khan, Ramsha (author)
- Toronto Platelet Immunobiology Group,Saint Michael's Hospital
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- Kim, Michael (author)
- Toronto Platelet Immunobiology Group,Saint Michael's Hospital
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- Brasseit, Jennifer (author)
- CSL Behring, Switzerland
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- Cruz-Leal, Yoelys (author)
- Toronto Platelet Immunobiology Group,Canadian Blood Services,Saint Michael's Hospital
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- Amash, Alaa (author)
- Toronto Platelet Immunobiology Group,Saint Michael's Hospital
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- Kahlon, Simrat (author)
- Toronto Platelet Immunobiology Group,Saint Michael's Hospital
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- Yougbare, Issaka (author)
- Toronto Platelet Immunobiology Group,Canadian Blood Services,Saint Michael's Hospital
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- Ni, Heyu (author)
- Saint Michael's Hospital,University of Toronto,Canadian Blood Services,Toronto Platelet Immunobiology Group
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- Zuercher, Adrian W. (author)
- CSL Behring, Switzerland
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- Käsermann, Fabian (author)
- CSL Behring, Switzerland
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- Semple, John W. (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Saint Michael's Hospital,Canadian Blood Services,University of Toronto,Toronto Platelet Immunobiology Group
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- Lazarus, Alan H. (author)
- Saint Michael's Hospital,Toronto Platelet Immunobiology Group,University of Toronto,Canadian Blood Services
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2019
- 2019
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 11:506
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Treatment of autoimmune and inflammatory diseases typically involves immune suppression. In an opposite strategy, we show that administration of the highly inflammatory erythrocyte-specific antibody Ter119 into mice remodels the monocyte cellular landscape, leading to resolution of inflammatory disease. Ter119 with intact Fc function was unexpectedly therapeutic in the K/BxN serum transfer model of arthritis. Similarly, it rapidly reversed clinical disease progression in collagen antibody-induced arthritis (CAIA) and collagen-induced arthritis and completely corrected CAIA-induced increase in monocyte Fcγ receptor II/III expression. Ter119 dose-dependently induced plasma chemokines CCL2, CCL5, CXCL9, CXCL10, and CCL11 with corresponding alterations in monocyte percentages in the blood and liver within 24 hours. Ter119 attenuated chemokine production from the synovial fluid and prevented the accumulation of inflammatory cells and complement components in the synovium. Ter119 could also accelerate the resolution of hypothermia and pulmonary edema in an acute lung injury model. We conclude that this inflammatory anti-erythrocyte antibody simultaneously triggers a highly efficient anti-inflammatory effect with broad therapeutic potential.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Crow, Andrew R.
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Kapur, Rick
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Koernig, Sandra
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Campbell, Ian K.
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Jen, Chao Ching
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Mott, Patrick J.
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show more...
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Marjoram, Daniel ...
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Khan, Ramsha
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Kim, Michael
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Brasseit, Jennif ...
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Cruz-Leal, Yoely ...
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Amash, Alaa
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Kahlon, Simrat
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Yougbare, Issaka
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Ni, Heyu
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Zuercher, Adrian ...
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Käsermann, Fabia ...
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Semple, John W.
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Lazarus, Alan H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Science Translat ...
- By the university
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Lund University