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  • van der Kwast, TheoPrincess Margaret Hospital University of Toronto (author)

International Society of Urological Pathology Expert Opinion on Grading of Urothelial Carcinoma

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:b0be8c33-2889-486b-b87d-2d49844c4146
  • https://lup.lub.lu.se/record/b0be8c33-2889-486b-b87d-2d49844c4146URI
  • https://doi.org/10.1016/j.euf.2021.03.017DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Context: Grading is the mainstay for treatment decisions for patients with non–muscle-invasive bladder cancer (NMIBC). Objective: To determine the requirements for an optimal grading system for NMIBC via expert opinion. Evidence acquisition: A multidisciplinary working group established by the International Society of Urological Pathology reviewed available clinical, histopathological, and molecular evidence for an optimal grading system for bladder cancer. Evidence synthesis: Bladder cancer grading is a continuum and five different grading systems based on historical grounds could be envisaged. Splitting of the World Health Organization (WHO) 2004 low-grade class for NMIBC lacks diagnostic reproducibility and molecular-genetic support, while showing little difference in progression rate. Subdividing the clinically heterogeneous WHO 2004 high-grade class for NMIBC into intermediate and high risk categories using the WHO 1973 grading is supported by both clinical and molecular-genetic findings. Grading criteria for the WHO 1973 scheme were detailed on the basis of literature findings and expert opinion. Conclusions: Splitting of the WHO 2004 high-grade category into WHO 1973 grade 2 and 3 subsets is recommended. Provision of more detailed histological criteria for the WHO 1973 grading might facilitate the general acceptance of a hybrid four-tiered grading system or—as a preferred option—a more reproducible three-tiered system distinguishing low-, intermediate (high)-, and high-grade NMIBC. Patient summary: Improvement of the current systems for grading bladder cancer may result in better informed treatment decisions for patients with bladder cancer. A three-tiered grading system for non–muscle invasive bladder cancer derived by splitting the heterogeneous World Health Organization (WHO) 2004 high-grade category into WHO 1973 grade 2 and 3 subsets is recommended, as this may result in more informed treatment decisions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Liedberg, FredrikLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)urok-fli (author)
  • Black, Peter C.University of British Columbia (author)
  • Kamat, AshishUniversity of Texas MD Anderson Cancer Center (author)
  • van Rhijn, Bas W.G.Antoni Van Leeuwenhoek Hospital (author)
  • Algaba, FerranAutonomous University of Barcelona (author)
  • Berman, David M.Queen's University at Kingston (author)
  • Hartmann, ArndtFriedrich-Alexander University Erlangen-Nürnberg (author)
  • Lopez-Beltran, AntonioUniversity of Córdoba, Spain (author)
  • Samaratunga, HemamaliUniversity of Queensland,Aquesta Uropathology (author)
  • Varma, MuraliUniversity Hospital of Wales (author)
  • Cheng, LiangIndiana University (author)
  • Princess Margaret Hospital University of TorontoUrologi - blåscancer, Malmö (creator_code:org_t)

Related titles

  • In:European Urology Focus: Elsevier BV8:2, s. 438-4462405-4569

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