Search: onr:"swepub:oai:lup.lub.lu.se:b0be8c33-2889-486b-b87d-2d49844c4146" >
International Socie...
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van der Kwast, TheoPrincess Margaret Hospital University of Toronto
(author)
International Society of Urological Pathology Expert Opinion on Grading of Urothelial Carcinoma
- Article/chapterEnglish2022
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LIBRIS-ID:oai:lup.lub.lu.se:b0be8c33-2889-486b-b87d-2d49844c4146
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https://lup.lub.lu.se/record/b0be8c33-2889-486b-b87d-2d49844c4146URI
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https://doi.org/10.1016/j.euf.2021.03.017DOI
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Context: Grading is the mainstay for treatment decisions for patients with non–muscle-invasive bladder cancer (NMIBC). Objective: To determine the requirements for an optimal grading system for NMIBC via expert opinion. Evidence acquisition: A multidisciplinary working group established by the International Society of Urological Pathology reviewed available clinical, histopathological, and molecular evidence for an optimal grading system for bladder cancer. Evidence synthesis: Bladder cancer grading is a continuum and five different grading systems based on historical grounds could be envisaged. Splitting of the World Health Organization (WHO) 2004 low-grade class for NMIBC lacks diagnostic reproducibility and molecular-genetic support, while showing little difference in progression rate. Subdividing the clinically heterogeneous WHO 2004 high-grade class for NMIBC into intermediate and high risk categories using the WHO 1973 grading is supported by both clinical and molecular-genetic findings. Grading criteria for the WHO 1973 scheme were detailed on the basis of literature findings and expert opinion. Conclusions: Splitting of the WHO 2004 high-grade category into WHO 1973 grade 2 and 3 subsets is recommended. Provision of more detailed histological criteria for the WHO 1973 grading might facilitate the general acceptance of a hybrid four-tiered grading system or—as a preferred option—a more reproducible three-tiered system distinguishing low-, intermediate (high)-, and high-grade NMIBC. Patient summary: Improvement of the current systems for grading bladder cancer may result in better informed treatment decisions for patients with bladder cancer. A three-tiered grading system for non–muscle invasive bladder cancer derived by splitting the heterogeneous World Health Organization (WHO) 2004 high-grade category into WHO 1973 grade 2 and 3 subsets is recommended, as this may result in more informed treatment decisions.
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Liedberg, FredrikLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)urok-fli
(author)
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Black, Peter C.University of British Columbia
(author)
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Kamat, AshishUniversity of Texas MD Anderson Cancer Center
(author)
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van Rhijn, Bas W.G.Antoni Van Leeuwenhoek Hospital
(author)
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Algaba, FerranAutonomous University of Barcelona
(author)
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Berman, David M.Queen's University at Kingston
(author)
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Hartmann, ArndtFriedrich-Alexander University Erlangen-Nürnberg
(author)
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Lopez-Beltran, AntonioUniversity of Córdoba, Spain
(author)
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Samaratunga, HemamaliUniversity of Queensland,Aquesta Uropathology
(author)
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Varma, MuraliUniversity Hospital of Wales
(author)
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Cheng, LiangIndiana University
(author)
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Princess Margaret Hospital University of TorontoUrologi - blåscancer, Malmö
(creator_code:org_t)
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In:European Urology Focus: Elsevier BV8:2, s. 438-4462405-4569
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Black, Peter C.
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Kamat, Ashish
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Berman, David M.
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Hartmann, Arndt
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Varma, Murali
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Cheng, Liang
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