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Real-world experien...
Real-world experience among patients with relapsed/refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure in Europe : The SCHOLAR-2 retrospective chart review study
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Hess, Georg (author)
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Dreyling, Martin (author)
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Oberic, Lucie (author)
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- Gine, Eva (author)
- Hospital Clínic of Barcelona
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Zinzani, Pier Luigi (author)
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Linton, Kim (author)
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- Vilmar, Adam (author)
- Odense University Hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund,Skåne University Hospital
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Chen, Jenny M.H. (author)
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Ohler, Anke (author)
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- Stilgenbauer, Stephan (author)
- University of Ulm
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- Thieblemont, Catherine (author)
- Université Paris Cité
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- Lambert, Jonathan (author)
- University College London Hospital
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- Zilioli, Vittorio Ruggero (author)
- Niguarda Hospital
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- Sancho, Juan Manuel (author)
- Hospital Universitari Germans Trias i Pujol
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- Ubieto, Ana Jimenez (author)
- 12 de Octubre University Hospital
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Fischer, Luca (author)
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- Eyre, Toby A. (author)
- Oxford University Hospitals NHS Foundation Trust
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Keeping, Sam (author)
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Park, Julie E. (author)
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Wu, James J. (author)
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Siddiqi, Rubina (author)
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Reitan, John (author)
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Wade, Sally (author)
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- Salles, Gilles (author)
- Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- 2022-10-18
- 2023
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 202:4, s. 749-759
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Abstract
Subject headings
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- Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory MCL in Europe who were treated with BTKi-based therapy between July 2012 and July 2018, and had experienced disease progression while on BTKi therapy or discontinued BTKi therapy due to intolerance. The median overall survival (OS) from initiation of first BTKi therapy was 14.6 months (95% confidence interval [CI] 11.6–20.0) in the overall cohort, 5.5 months (95% CI 3.9–8.2) in 91 patients without post-BTKi therapy, and 23.8 months (95% CI 18.9–30.1) in 149 patients who received post-BTKi therapy (excluding chimeric antigen receptor T-cell treatment). In the latter group, patients received a median of one (range, one to seven) line of post-BTKi therapy, with lenalidomide-containing regimens and bendamustine plus rituximab being the most frequently administered; the median OS from initiation of first post-BTKi therapy was 9.7 months (95% CI 6.3–12.7). These results provide a benchmark for survival in patients with R/R MCL receiving salvage therapy after BTKi failure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Bruton tyrosine kinase inhibitor
- mantle cell lymphoma
- post-BTKi
- real-world evidence
- survival
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hess, Georg
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Dreyling, Martin
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Oberic, Lucie
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Gine, Eva
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Zinzani, Pier Lu ...
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Linton, Kim
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show more...
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Vilmar, Adam
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Jerkeman, Mats
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Chen, Jenny M.H.
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Ohler, Anke
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Stilgenbauer, St ...
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Thieblemont, Cat ...
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Lambert, Jonatha ...
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Zilioli, Vittori ...
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Sancho, Juan Man ...
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Ubieto, Ana Jime ...
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Fischer, Luca
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Eyre, Toby A.
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Keeping, Sam
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Park, Julie E.
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Wu, James J.
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Siddiqi, Rubina
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Reitan, John
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Wade, Sally
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Salles, Gilles
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Lund University