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Metabolic pathways ...
Metabolic pathways in immune senescence and inflammaging : Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology
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- Roth-Walter, F. (author)
- University of Veterinary Medicine Vienna
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- Adcock, I. M. (author)
- Imperial College London
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- Benito-Villalvilla, C. (author)
- Complutense University of Madrid
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- Bianchini, R. (author)
- University of Veterinary Medicine Vienna
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- Bjermer, L. (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Respiratory Medicine,Lund University Research Groups
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- Caramori, G. (author)
- University of Parma
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- Cari, L. (author)
- University of Perugia
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- Chung, K. F. (author)
- Royal Brompton and Harefield NHS Foundation Trust
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- Diamant, Z. (author)
- Charles University in Prague,Skåne University Hospital,University Medical Center Groningen
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- Eguiluz-Gracia, I. (author)
- University of Malaga
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- Knol, E. F. (author)
- University Medical Center Utrecht
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- Jesenak, M. (author)
- Comenius University
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Levi-Schaffer, F. (author)
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- Nocentini, G. (author)
- University of Perugia
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- O'Mahony, L. (author)
- University College Cork
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- Palomares, O. (author)
- Complutense University of Madrid
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- Redegeld, F. (author)
- Utrecht University
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- Sokolowska, M. (author)
- University of Zurich,Christine Kühne Center for Allergy Research and Education (CK-CARE)
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- Van Esch, B. C.A.M. (author)
- Utrecht University
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- Stellato, C. (author)
- University of Salerno
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(creator_code:org_t)
- 2024
- 2024
- English 34 s.
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In: Allergy: European Journal of Allergy and Clinical Immunology. - 0105-4538. ; 79:5, s. 1089-1122
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Abstract
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- The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation. Metabolic changes imposed by environmental stress and inflammation on immune cells and tissue microenvironment are thus chiefly involved in the pathophysiology of allergic and other immune-driven diseases. Altered cell metabolism is also a hallmark of cell senescence, a condition characterized by loss of proliferative activity in cells that remain metabolically active. Accelerated senescence can be triggered by acute or chronic stress and inflammatory responses. In contrast, replicative senescence occurs as part of the physiological aging process and has protective roles in cancer surveillance and wound healing. Importantly, cell senescence can also change or hamper response to diverse therapeutic treatments. Understanding the metabolic pathways of senescence in immune and structural cells is therefore critical to detect, prevent, or revert detrimental aspects of senescence-related immunopathology, by developing specific diagnostics and targeted therapies. In this paper, we review the main changes and metabolic alterations occurring in senescent immune cells (macrophages, B cells, T cells). Subsequently, we present the metabolic footprints described in translational studies in patients with chronic asthma and chronic obstructive pulmonary disease (COPD), and review the ongoing preclinical studies and clinical trials of therapeutic approaches aiming at targeting metabolic pathways to antagonize pathological senescence. Because this is a recently emerging field in allergy and clinical immunology, a better understanding of the metabolic profile of the complex landscape of cell senescence is needed. The progress achieved so far is already providing opportunities for new therapies, as well as for strategies aimed at disease prevention and supporting healthy aging.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- cell metabolism
- immune senescence
- immunometabolism
- inflammaging
- senolytic drugs
- senomorphic drugs
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Roth-Walter, F.
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Adcock, I. M.
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Benito-Villalvil ...
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Bianchini, R.
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Bjermer, L.
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Caramori, G.
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show more...
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Cari, L.
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Chung, K. F.
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Diamant, Z.
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Eguiluz-Gracia, ...
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Knol, E. F.
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Jesenak, M.
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Levi-Schaffer, F ...
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Nocentini, G.
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O'Mahony, L.
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Palomares, O.
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Redegeld, F.
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Sokolowska, M.
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Van Esch, B. C.A ...
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Stellato, C.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Allergy: Europea ...
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Lund University