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Beta1 integrin is n...
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
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- Brakebusch, Cord (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Fillatreau, Simon (author)
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Potocnik, Alexandre J (author)
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Bungartz, Gerd (author)
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Wilhelm, Patricia (author)
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- Svensson Frej, Marcus (author)
- Lund University,Lunds universitet,Eosinofilers biologi,Forskargrupper vid Lunds universitet,Eosinophil Biology,Lund University Research Groups
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Kearney, Phil (author)
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Körner, Heinrich (author)
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Gray, David (author)
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- Fässler, Reinhard (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Immunity. - 1074-7613. ; 16:3, s. 465-477
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- CD29 : immunology
- Antigens
- CD29 : genetics
- Hematopoiesis : genetics
- Gene Expression Regulation : immunology
- Gene Deletion
- B-Lymphocytes : immunology
- Immunoglobulin M : biosynthesis
- Immunoglobulin M : genetics
- Immunoglobulin M : immunology
- Mice
- Support
- Non-U.S. Gov't
- T-Lymphocytes : immunology
- Antibody Formation : immunology
- Animal
- Antibody Formation : genetics
Publication and Content Type
- art (subject category)
- ref (subject category)
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Immunity
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- By the author/editor
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Brakebusch, Cord
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Fillatreau, Simo ...
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Potocnik, Alexan ...
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Bungartz, Gerd
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Wilhelm, Patrici ...
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Svensson Frej, M ...
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show more...
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Kearney, Phil
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Körner, Heinrich
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Gray, David
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Fässler, Reinhar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Immunity
- By the university
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Lund University