Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

• Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

CD29 : immunology

Antigens

CD29 : genetics

Hematopoiesis : genetics

Gene Expression Regulation : immunology

Gene Deletion

B-Lymphocytes : immunology

Immunoglobulin M : biosynthesis

Immunoglobulin M : genetics

Immunoglobulin M : immunology

Mice

Support

Non-U.S. Gov't

T-Lymphocytes : immunology

Antibody Formation : immunology

Animal

Antibody Formation : genetics

Publication and Content Type

art (subject category)

ref (subject category)