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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03514naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:b1f6363a-cc59-4c29-bee5-331322a4c67d | |
| 003 | SwePub | |
| 008 | 160401s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11223222 URI |
| 024 | 7 | a https://doi.org/10.1016/S0300-483X(00)00331-02 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Hultberg, Björnu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kkem-bhu |
| 245 | 1 0 | a Interaction of metals and thiols in cell damage and glutathione distribution: potentiation of mercury toxicity by dithiothreitol |
| 264 | 1 | c 2001 |
| 520 | a In the present study, we have investigated the effects of extracellular redox status and metal/thiol interactions on glutathione distribution in HeLa cell cultures. No effects were seen on glutathione distribution after the addition of different thiols, whereas the pro-oxidant copper ions affected glutathione distribution in several ways. The addition of dithiothreitol (DTT) but not the other thiols potentiated the effects of mercury ions on glutathione distribution and cell toxicity. In the presence of DTT, increased intra- and extracellular glutathione concentrations were noted already at 0.05 micromol/l, which was below the previously reported toxicity threshold for mercury ions in blood. Likewise DTT potentiated the effects of copper ions on glutathione distribution and cell toxicity, whereas the addition of DTT to cell cultures with a non-metal thiol reactive agent (hydroquinone) or an oxidative agent (hydrogen peroxide) did not affect glutathione distribution or cell toxicity. Thus, it seems as the synergistic effects between DTT and thiol reactive agents only apply to metal ions. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
| 653 | a Cell culture | |
| 653 | a Copper ions | |
| 653 | a Dithiothreitol | |
| 653 | a Glutathione | |
| 653 | a Homocysteine | |
| 653 | a Hydrogen peroxide | |
| 653 | a Hydroquinone | |
| 653 | a Mercury ions | |
| 653 | a N-acetylcysteine | |
| 700 | 1 | a Andersson, Anders4 aut |
| 700 | 1 | a Isaksson, Andersu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kkem-ais |
| 710 | 2 | a Avdelningen för klinisk kemi och farmakologib Institutionen för laboratoriemedicin4 org |
| 773 | 0 | t Toxicologyg 156:2-3, s. 93-100q 156:2-3<93-100x 0300-483X |
| 856 | 4 | u http://dx.doi.org/10.1016/S0300-483X(00)00331-0y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1122322 |
| 856 | 4 8 | u https://doi.org/10.1016/S0300-483X(00)00331-0 |
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