Search: onr:"swepub:oai:lup.lub.lu.se:b2374eac-85fc-43a3-ae93-ef61967a98ed" > Genome-Wide Associa...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07522naa a2200865 4500 | |
001 | oai:lup.lub.lu.se:b2374eac-85fc-43a3-ae93-ef61967a98ed | |
003 | SwePub | |
008 | 210120s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-180264 | |
024 | 7 | a https://lup.lub.lu.se/record/b2374eac-85fc-43a3-ae93-ef61967a98ed2 URI |
024 | 7 | a https://doi.org/10.1210/clinem/dgaa6532 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1802642 URI |
040 | a (SwePub)lud (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Deshmukh, Harshal A.u University of Newcastle upon Tyne,University of Copenhagen4 aut |
245 | 1 0 | a Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity |
264 | c 2020-09-18 | |
264 | 1 | b The Endocrine Society,c 2021 |
300 | a 11 s. | |
520 | a CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. OBJECTIVE: To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies. DESIGN: We performed a genome-wide meta-analysis for beta-cell glucose sensitivity in subjects with type 2 diabetes and nondiabetic subjects from 6 independent cohorts (n = 5706). Beta-cell glucose sensitivity was calculated from mixed meal and oral glucose tolerance tests, and its associations between known glycemia-related single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) SNPs were estimated using linear regression models. RESULTS: Beta-cell glucose sensitivity was moderately heritable (h2 ranged from 34% to 55%) using SNP and family-based analyses. GWAS meta-analysis identified multiple correlated SNPs in the CDKAL1 gene and GIPR-QPCTL gene loci that reached genome-wide significance, with SNP rs2238691 in GIPR-QPCTL (P value = 2.64 × 10-9) and rs9368219 in the CDKAL1 (P value = 3.15 × 10-9) showing the strongest association with beta-cell glucose sensitivity. These loci surpassed genome-wide significance when the GWAS meta-analysis was repeated after exclusion of the diabetic subjects. After correction for multiple testing, glycemia-associated SNPs in or near the HHEX and IGF2B2 loci were also associated with beta-cell glucose sensitivity. CONCLUSION: We show that, variation at the GIPR-QPCTL and CDKAL1 loci are key determinants of pancreatic beta-cell glucose sensitivity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a beta-cell function | |
653 | a diabetes progression | |
653 | a Glucose intolerance | |
653 | a incretin | |
653 | a mathematical model | |
653 | a Glucose intolerance | |
700 | 1 | a Madsen, Anne Lundageru University of Copenhagen4 aut |
700 | 1 | a Viñuela, Anau University of Geneva4 aut |
700 | 1 | a Have, Christian Theilu University of Copenhagen4 aut |
700 | 1 | a Grarup, Nielsu University of Copenhagen4 aut |
700 | 1 | a Tura, Andreau Institute of Neuroscience, Università di Padova4 aut |
700 | 1 | a Mahajan, Anubhau University of Oxford4 aut |
700 | 1 | a Heggie, Alison J.u University of Newcastle upon Tyne4 aut |
700 | 1 | a Koivula, Robert W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital,University of Oxford4 aut0 (Swepub:lu)med-rkl |
700 | 1 | a De Masi, Federicou Technical University of Denmark4 aut |
700 | 1 | a Tsirigos, Konstantinos K.u Technical University of Denmark4 aut |
700 | 1 | a Linneberg, Allanu University of Copenhagen,Frederiksberg Hospital4 aut |
700 | 1 | a Drivsholm, Thomasu Frederiksberg Hospital,University of Copenhagen4 aut |
700 | 1 | a Pedersen, Olufu University of Copenhagen4 aut |
700 | 1 | a Sørensen, Thorkild I.A.u University of Copenhagen4 aut |
700 | 1 | a Astrup, Arneu University of Copenhagen4 aut |
700 | 1 | a Gjesing, Anette A.P.u University of Copenhagen4 aut |
700 | 1 | a Pavo, Imreu Eli Lilly Regional Operations G.m.b.H.4 aut |
700 | 1 | a Wood, Andrew R.u University of Exeter4 aut |
700 | 1 | a Ruetten, Hartmutu Sanofi-Aventis Deutschland GmbH4 aut |
700 | 1 | a Jones, Angus G.u University of Exeter4 aut |
700 | 1 | a Koopman, Anitra D.M.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Cederberg, Hennau Helsinki University Central Hospital4 aut |
700 | 1 | a Rutters, Femkeu Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Ridderstrale, Martinu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-mri |
700 | 1 | a Laakso, Markkuu University of Eastern Finland4 aut |
700 | 1 | a McCarthy, Mark I.u University of Oxford4 aut |
700 | 1 | a Frayling, Tim M.u University of Exeter4 aut |
700 | 1 | a Ferrannini, Eleu CNR Institute of Clinical Physiology (IFC-CNR)4 aut |
700 | 1 | a Franks, Paul W.u Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, UK; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Lund University, Sweden; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts,Harvard University,Skåne University Hospital,Avdelningen för medicin4 aut0 (Swepub:umu)pafr0003 |
700 | 1 | a Pearson, Ewan R.u University of Dundee4 aut0 (Swepub:lu)ew1481pe |
700 | 1 | a Mari, Andreau Institute of Neuroscience, Università di Padova4 aut |
700 | 1 | a Hansen, Torbenu University of Copenhagen4 aut |
700 | 1 | a Walker, Marku University of Newcastle upon Tyne4 aut |
710 | 2 | a University of Newcastle upon Tyneb University of Copenhagen4 org |
773 | 0 | t The Journal of clinical endocrinology and metabolismd : The Endocrine Societyg 106:1, s. 80-90q 106:1<80-90x 1945-7197x 0021-972X |
856 | 4 | u http://dx.doi.org/10.1210/clinem/dgaa653x freey FULLTEXT |
856 | 4 | u https://academic.oup.com/jcem/article-pdf/106/1/80/36661744/dgaa653.pdf |
856 | 4 | u https://doi.org/10.1210/clinem/dgaa653y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1528593/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://lup.lub.lu.se/record/b2374eac-85fc-43a3-ae93-ef61967a98ed |
856 | 4 8 | u https://doi.org/10.1210/clinem/dgaa653 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180264 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.