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PAM50 provides prog...
PAM50 provides prognostic information when applied to the lymph node metastases of advanced breast cancer patients
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- Tobin, Nicholas P. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Lundberg, Arian (author)
- Karolinska Institutet,Karolinska University Hospital
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- Lindström, Linda S. (author)
- Karolinska Institutet
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- Harrell, J. Chuck (author)
- Virginia Commonwealth University
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- Foukakis, Theodoros (author)
- Karolinska Institutet,Karolinska University Hospital
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- Carlsson, Lena (author)
- Sundsvall Hospital
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- Einbeigi, Zakaria (author)
- Sahlgrenska University Hospital
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- Linderholm, Barbro K. (author)
- Karolinska Institutet,Karolinska University Hospital,Sahlgrenska University Hospital
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- Loman, Niklas (author)
- Skåne University Hospital
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- Malmberg, Martin (author)
- Skåne University Hospital,University of North Carolina
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- Fernö, Mårten (author)
- Lund University,Lunds universitet,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,Personalized Breast Cancer Treatment,Lund University Research Groups
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- Czene, Kamila (author)
- Karolinska Institutet
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- Perou, Charles M. (author)
- University of North Carolina
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- Bergh, Jonas (author)
- Karolinska Institutet,Karolinska University Hospital,University of Oxford
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- Hatschek, Thomas (author)
- Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
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- 2017
- 2017
- English 7 s.
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In: Clinical Cancer Research. - 1078-0432. ; 23:23, s. 7225-7231
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http://dx.doi.org/10...
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Abstract
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- Purpose: Transcriptional pathway activity and the molecular subtypes of breast cancer metastases have been shown to significantly influence patient postrelapse survival. Here, we further determine the relevance of clinically employed gene signatures in the advanced breast cancer (ABC) setting. Experimental Design: Sufficient RNA for expression profiling was obtained from distant metastatic or inoperable locoregional relapse tissue by fine-needle aspiration from 109 patients of the Swedish TEX clinical trial. Gene signatures (GGI, 70 gene, recurrence score, cell-cycle score, risk of recurrence score, and PAM50) were applied to all metastases, and their relationship to long- (5-year) and short-term (1.5-year) postrelapse survival at all and locoregional lymph nodes (n = 40) versus other metastatic sites (n = 69) combined was assessed using Kaplan–Meier and/or multivariate Cox regression analyses. Results: The majority of metastases were classified into intermediate or high-risk groups by all signatures, and a significant association was found between metastatic signature subgroups and primary tumor estrogen receptor status and histologic grade (P < 0.05). When considering all sites of metastasis, only PAM50 was statistically significant in Kaplan–Meier analysis (Log-rank P = 0.008 and 0.008 for long- and short-term postrelapse breast cancer–specific survival, respectively). This significance remained in both uni- and multivariate models when restricting analyses to lymph node metastases only, and a similar trend was observed in other metastatic sites combined, but did not reach formal significance. Conclusions: Our findings are the first to demonstrate that the PAM50 signature can provide prognostic information from the lymph node metastases of ABC patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Tobin, Nicholas ...
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Lundberg, Arian
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Lindström, Linda ...
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Harrell, J. Chuc ...
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Foukakis, Theodo ...
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Carlsson, Lena
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show more...
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Einbeigi, Zakari ...
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Linderholm, Barb ...
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Loman, Niklas
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Malmberg, Martin
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Fernö, Mårten
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Czene, Kamila
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Perou, Charles M ...
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Bergh, Jonas
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Hatschek, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Clinical Cancer ...
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Clinical cancer ...
- By the university
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Lund University
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Karolinska Institutet