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Time between anteri...
Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction
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- Davis, Hope C. (author)
- University of North Carolina
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- Spang, Jeffery T. (author)
- University of North Carolina
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- Loeser, Richard F. (author)
- University of North Carolina
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- Larsson, Staffan (author)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups
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- Ulici, Veronica (author)
- University of North Carolina
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- Troy Blackburn, J. (author)
- University of North Carolina
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- Creighton, R. Alexander (author)
- University of North Carolina
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- Kamath, Ganesh M. (author)
- University of North Carolina
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- Jordan, Joanne M. (author)
- University of North Carolina
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- Marshall, Stephen W. (author)
- University of North Carolina
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- Pietrosimone, Brian (author)
- University of North Carolina
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Knee. - : Elsevier BV. - 0968-0160. ; 25:2, s. 296-305
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
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- Background: To determine the association between time from injury to ACL reconstruction (TimeInjury-ACLR) and biochemical markers of cartilage metabolism and inflammation six months following ACL reconstruction (ACLR). Methods: Individuals with a unilateral ACL injury were enrolled at initial presentation in the orthopedic clinic; blood was collected six months following ACLR. Enzyme-linked immunosorbent assays were used to analyze the ratio of serum concentrations of type-II collagen breakdown (C2C) to synthesis (CPII), plasma matrix metalloproteinase-3 (MMP-3), interleukin-6 (IL-6), and serum aggrecan neoepitope (ARGS). We used separate linear regressions to assess associations between biochemical markers and TimeInjury-ACLR. Results: Twenty-two participants (50% females, mean [SD], age 21.9 [4.5] years old; BMI 23.8 [2.6] kg/m2) completed the study. TimeInjury-ACLR ranged from nine to 67days (31.0 [14.4days]). Greater TimeInjury-ACLR predicted greater serum C2C:CPII ratios six months following ACLR (C2C:CPII=0.15 [0.02], R2 =0.213, P=0.030). Males (R2 =0.733, P=0.001) but not females (R2 =0.030, P=0.609) demonstrated a significant association between greater C2C:CPII and TimeInjury-ACLR at the six-month follow-up exam. TimeInjury-ACLR did not associate with IL-6, MMP-3, or ARGS at six months. Conclusions: Greater time between injury and ACL reconstruction was associated with greater serum C2C:CPII six months following ACLR in males but not females, and IL-6, MMP-3, and ARGS levels were not associated with TimeInjury-ACLR in males or females. The time between ACL injury and ACLR may affect collagen metabolism in males and should be further investigated in a larger study along with other patient-relevant outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- ACLR
- Biomarkers
- C-propeptide of type II procollagen
- C2C
- CPII
- Type-II collagen cleavage product
Publication and Content Type
- art (subject category)
- ref (subject category)
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Knee
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- By the author/editor
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Davis, Hope C.
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Spang, Jeffery T ...
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Loeser, Richard ...
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Larsson, Staffan
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Ulici, Veronica
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Troy Blackburn, ...
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show more...
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Creighton, R. Al ...
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Kamath, Ganesh M ...
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Jordan, Joanne M ...
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Marshall, Stephe ...
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Pietrosimone, Br ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Knee
- By the university
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Lund University