Search: onr:"swepub:oai:lup.lub.lu.se:b30aaadb-6987-496e-a8cb-d28c5f3f7b5f" >
Leukocyte telomere ...
Leukocyte telomere length predicts SSRI response in major depressive disorder : A preliminary report
-
- Hough, Christina M (author)
- University of California, San Francisco
-
- Bersani, F Saverio (author)
- Sapienza University of Rome,University of California, San Francisco
-
- Mellon, Synthia H (author)
- University of California, San Francisco
-
show more...
-
- Epel, Elissa S (author)
- University of California, San Francisco
-
- Reus, Victor I (author)
- University of California, San Francisco
-
- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, San Francisco
-
Reus, Victor I (author)
-
- Mahan, Laura (author)
- University of California, San Francisco
-
- Rosser, Rebecca (author)
- University of California, San Francisco
-
- Burke, Heather (author)
- University of California, San Francisco
-
- Coetzee, John (author)
- University of California, San Francisco
-
- Nelson, J Craig (author)
- University of California, San Francisco
-
- Blackburn, Elizabeth H (author)
- University of California, San Francisco
-
- Wolkowitz, Owen M (author)
- University of California, San Francisco
-
show less...
-
(creator_code:org_t)
- 2016-06-22
- 2016
- English 9 s.
-
In: Molecular Neuropsychiatry. - : S. Karger AG. - 2296-9209. ; :2, s. 88-96
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://www.ncbi.nlm...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD. Subjects then underwent open-label treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant for eight weeks, after which clinical ratings were repeated. Analyses were corrected for age, sex and BMI. "Non-responders" to treatment (HDRS improvement <50%) had significantly shorter pre-treatment LTL, compared to "Responders" (p=0.037). Further, shorter pre-treatment LTL was associated with less improvement in negative affect (p<0.010) but not with changes in positive affect (p=0.356). This preliminary study is the first to assess the relationship between LTL and SSRI response in MDD and among the first to prospectively assess its relationship to treatment outcome in any psychiatric illness. Our data suggest that short LTL may serve as a vulnerability index of poorer response to SSRI treatment, but this needs examination in larger samples.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hough, Christina ...
-
Bersani, F Saver ...
-
Mellon, Synthia ...
-
Epel, Elissa S
-
Reus, Victor I
-
Lindqvist, Danie ...
-
show more...
-
Mahan, Laura
-
Rosser, Rebecca
-
Burke, Heather
-
Coetzee, John
-
Nelson, J Craig
-
Blackburn, Eliza ...
-
Wolkowitz, Owen ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Molecular Neurop ...
-
Complex Psychiat ...
- By the university
-
Lund University