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Expression patterns...
Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma : a study of younger patients from the MCL2 and MCL3 clinical trials
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- Dahl, Mette (author)
- Copenhagen University Hospital,University of Copenhagen
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- Husby, Simon (author)
- University of Copenhagen,Copenhagen University Hospital
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- Eskelund, Christian W. (author)
- University of Copenhagen,Copenhagen University Hospital
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- Besenbacher, Søren (author)
- Aarhus University
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- Fjelstrup, Søren (author)
- Aarhus University
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- Côme, Christophe (author)
- Copenhagen University Hospital,University of Copenhagen
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- Ek, Sara (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Kolstad, Arne (author)
- Norwegian Radium Hospital
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- Räty, Riikka (author)
- Helsinki University Central Hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Geisler, Christian H. (author)
- Copenhagen University Hospital
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- Kjems, Jørgen (author)
- Aarhus University
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- Kristensen, Lasse S. (author)
- Aarhus University
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- Grønbæk, Kirsten (author)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2021-07-09
- 2022
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 36:1, s. 177-188
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http://dx.doi.org/10...
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Abstract
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- Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL. We profiled the circRNA expression landscape using RNA-sequencing and explored the prognostic potential of 40 abundant circRNAs in samples from the Nordic MCL2 and MCL3 clinical trials, using NanoString nCounter Technology. We report a circRNA-based signature (circSCORE) developed in the training cohort MCL2 that is highly predictive of time to progression (TTP) and lymphoma-specific survival (LSS). The dismal outcome observed in the large proportion of patients assigned to the circSCORE high-risk group was confirmed in the independent validation cohort MCL3, both in terms of TTP (HR 3.0; P = 0.0004) and LSS (HR 3.6; P = 0.001). In Cox multiple regression analysis incorporating MIPI, Ki67 index, blastoid morphology and presence of TP53 mutations, circSCORE retained prognostic significance for TTP (HR 3.2; P = 0.01) and LSS (HR 4.6; P = 0.01). In conclusion, circRNAs are promising prognostic biomarkers in MCL and circSCORE improves identification of high-risk disease among younger patients treated with cytarabine-containing chemoimmunotherapy and autologous stem cell transplant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
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Leukemia
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- By the author/editor
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Dahl, Mette
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Husby, Simon
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Eskelund, Christ ...
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Besenbacher, Sør ...
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Fjelstrup, Søren
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Côme, Christophe
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show more...
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Ek, Sara
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Kolstad, Arne
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Räty, Riikka
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Jerkeman, Mats
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Geisler, Christi ...
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Kjems, Jørgen
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Kristensen, Lass ...
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Grønbæk, Kirsten
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia
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Lund University