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A variant within th...
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
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- Taira, Makiko (author)
- RIKEN Center for Integrative Medical Sciences
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- Imamura, Minako (author)
- University of the Ryukyus,RIKEN Center for Integrative Medical Sciences,University Hospital Of The Ryukyus
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- Takahashi, Atsushi (author)
- RIKEN Center for Integrative Medical Sciences,National Cerebral and Cardiovascular Center
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- Kamatani, Yoichiro (author)
- RIKEN Center for Integrative Medical Sciences,Kyoto University
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- Yamauchi, Toshimasa (author)
- University of Tokyo
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- Araki, Shin ichi (author)
- Shiga University of Medical Science
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- Tanaka, Nobue (author)
- Tokyo Women's Medical University
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- Van Zuydam, Natalie R. (author)
- University of Oxford
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Toyoda, Masao (author)
- Tokai University
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- Umezono, Tomoya (author)
- Tokai University
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- Kawai, Koichi (author)
- Kawai Clinic
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- Imanishi, Masahito (author)
- Ishikiri Seiki Hospital,Osaka City General Hospital
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- Watada, Hirotaka (author)
- Juntendo University
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- Suzuki, Daisuke (author)
- Suzuki Diabetes Clinic
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- Maegawa, Hiroshi (author)
- Shiga University of Medical Science
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- Babazono, Tetsuya (author)
- Tokyo Women's Medical University
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- Kaku, Kohei (author)
- Kawasaki Medical School
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- Kawamori, Ryuzo (author)
- Juntendo University
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- Groop, Leif C. (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
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- McCarthy, Mark I. (author)
- Oxford University Hospital,University of Oxford
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- Kadowaki, Takashi (author)
- University of Tokyo,Teikyo University
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- Maeda, Shiro (author)
- RIKEN Center for Integrative Medical Sciences,University Hospital Of The Ryukyus,University of the Ryukyus
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(creator_code:org_t)
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- 2018-12-19
- 2018
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:12
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 × 10−4) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 × 10−10. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 × 10−10). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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PLoS ONE
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- By the author/editor
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Taira, Makiko
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Imamura, Minako
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Takahashi, Atsus ...
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Kamatani, Yoichi ...
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Yamauchi, Toshim ...
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Araki, Shin ichi
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show more...
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Tanaka, Nobue
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Van Zuydam, Nata ...
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Ahlqvist, Emma
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Toyoda, Masao
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Umezono, Tomoya
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Kawai, Koichi
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Imanishi, Masahi ...
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Watada, Hirotaka
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Suzuki, Daisuke
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Maegawa, Hiroshi
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Babazono, Tetsuy ...
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Kaku, Kohei
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Kawamori, Ryuzo
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Groop, Leif C.
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McCarthy, Mark I ...
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Kadowaki, Takash ...
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Maeda, Shiro
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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PLoS ONE
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Lund University