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Development and val...
Development and validation of language and visuospatial composite scores in ADNI
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- Choi, Seo Eun (author)
- Washington University School of Medicine
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- Mukherjee, Shubhabrata (author)
- Washington University School of Medicine
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- Gibbons, Laura E. (author)
- Washington University School of Medicine
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- Sanders, R. Elizabeth (author)
- Washington University School of Medicine
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- Jones, Richard N. (author)
- Brown University
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- Tommet, Douglas (author)
- Brown University
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- Mez, Jesse (author)
- Boston University
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- Trittschuh, Emily H. (author)
- University of Washington
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- Saykin, Andrew (author)
- Indiana University-Purdue University Indianapolis
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- Lamar, Melissa (author)
- Rush Alzheimer's Disease Center
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- Rabin, Laura (author)
- City University of New York
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- Foldi, Nancy S. (author)
- City University of New York
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- Sikkes, Sietske (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Jutten, Roos J. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Grandoit, Evan (author)
- Northwestern University
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- MacDonald, Christine (author)
- University of Washington
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- Risacher, Shannon (author)
- Indiana University-Purdue University Indianapolis
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- Groot, Colin (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Crane, Paul K. (author)
- Washington University School of Medicine
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(creator_code:org_t)
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- 2020-12-05
- 2020
- English.
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In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. - : Wiley. - 2352-8737. ; 6:1
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Abstract
Subject headings
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- Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods:We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer’s disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results: ADNI-Lan andADNI-VSwere able to detect change over time and predict conversion fromMCI toAD. Theywere associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern. Discussion: ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Alzheimer’s Disease Neuroimaging Initiative
- cognition
- language
- longitudinal analysis
- magnetic resonance imaging
- psychometrics
- visuospatial functioning
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Choi, Seo Eun
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Mukherjee, Shubh ...
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Gibbons, Laura E ...
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Sanders, R. Eliz ...
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Jones, Richard N ...
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Tommet, Douglas
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show more...
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Mez, Jesse
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Trittschuh, Emil ...
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Saykin, Andrew
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Lamar, Melissa
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Rabin, Laura
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Foldi, Nancy S.
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Sikkes, Sietske
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Jutten, Roos J.
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Grandoit, Evan
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MacDonald, Chris ...
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Risacher, Shanno ...
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Groot, Colin
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Ossenkoppele, Ri ...
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Crane, Paul K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
- Articles in the publication
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Alzheimer's and ...
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Lund University