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- Hansen, Jesper S.Lund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups (author)
Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-11-08
- Springer Science and Business Media LLC,2017
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- LIBRIS-ID:oai:lup.lub.lu.se:b422b6b2-1087-4ffb-b7a5-8ece37dc4af3
- https://lup.lub.lu.se/record/b422b6b2-1087-4ffb-b7a5-8ece37dc4af3URI
- https://doi.org/10.1038/s41598-017-15059-4DOI
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- Language:English
- Summary in:English
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- Perilipin 1 is a lipid droplet coating protein known to regulate lipid metabolism in adipocytes by serving as a physical barrier as well as a recruitment site for lipases to the lipid droplet. Phosphorylation of perilipin 1 by protein kinase A rapidly initiates lipolysis, but the detailed mechanism on how perilipin 1 controls lipolysis is unknown. Here, we identify specific lipid binding properties of perilipin 1 that regulate the dynamics of lipolysis in human primary adipocytes. Cellular imaging combined with biochemical and biophysical analyses demonstrate that perilipin 1 specifically binds to cholesteryl esters, and that their dynamic properties direct segregation of perilipin 1 into topologically distinct micro domains on the lipid droplet. Together, our data points to a simple unifying mechanism that lipid assembly and segregation control lipolysis in human primary adipocytes.
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- De Maré, SofiaLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)med-sid (author)
- Jones, Helena A.Lund University,Lunds universitet,Molekylär endokrinologi,Forskargrupper vid Lunds universitet,Molecular Endocrinology,Lund University Research Groups(Swepub:lu)medk-hwa (author)
- Göransson, OlgaLund University,Lunds universitet,Proteinfosforylering,Forskargrupper vid Lunds universitet,Protein Phosphorylation,Lund University Research Groups(Swepub:lu)medk-ogo (author)
- Lindkvist-Petersson, KarinLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)mbfy-kpe (author)
- Medicinsk strukturbiologiForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:Scientific Reports: Springer Science and Business Media LLC7:12045-2322
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