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Pig-to-non-human pr...
Pig-to-non-human primate heart transplantation : The final step toward clinical xenotransplantation?
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- Reichart, Bruno (author)
- Ludwig-Maximilian University of Munich
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- Längin, Matthias (author)
- University Hospital Munich
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- Radan, Julia (author)
- Ludwig-Maximilian University of Munich
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- Mokelke, Maren (author)
- Ludwig-Maximilian University of Munich
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- Buttgereit, Ines (author)
- Ludwig-Maximilian University of Munich
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- Ying, Jiawei (author)
- Ludwig-Maximilian University of Munich
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- Fresch, Ann Kathrin (author)
- Ludwig-Maximilian University of Munich
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- Mayr, Tanja (author)
- University Hospital Munich
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- Issl, Lara (author)
- Ludwig-Maximilian University of Munich
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- Buchholz, Stefan (author)
- University Hospital Munich
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- Michel, Sebastian (author)
- University Hospital Munich
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- Ellgass, Reinhard (author)
- University Hospital Munich
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- Mihalj, Maks (author)
- Bern University Hospital
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- Egerer, Stefanie (author)
- Ludwig-Maximilian University of Munich
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- Baehr, Andrea (author)
- Ludwig-Maximilian University of Munich
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- Kessler, Barbara (author)
- Ludwig-Maximilian University of Munich
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- Kemter, Elisabeth (author)
- Ludwig-Maximilian University of Munich
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- Kurome, Mayuko (author)
- Ludwig-Maximilian University of Munich
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- Zakhartchenko, Valeri (author)
- Ludwig-Maximilian University of Munich
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- Steen, Stig (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Sjöberg, Trygve (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Paskevicius, Audrius (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Krüger, Luise (author)
- Robert Koch Institut
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- Fiebig, Uwe (author)
- Robert Koch Institut
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- Denner, Joachim (author)
- Robert Koch Institut
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- Godehardt, Antonia W. (author)
- Paul Ehrlich Institute
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- Tönjes, Ralf R. (author)
- Paul Ehrlich Institute
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- Milusev, Anastasia (author)
- University of Bern
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- Rieben, Robert (author)
- University of Bern
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- Sfriso, Riccardo (author)
- University of Bern
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- Walz, Christoph (author)
- Ludwig-Maximilian University of Munich
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- Kirchner, Thomas (author)
- Ludwig-Maximilian University of Munich
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- Ayares, David (author)
- Revivicor, Inc
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- Lampe, Karen (author)
- German Primate Center
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- Schönmann, Uwe (author)
- German Primate Center
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- Hagl, Christian (author)
- University Hospital Munich
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- Wolf, Eckhard (author)
- Ludwig-Maximilian University of Munich
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- Klymiuk, Nikolai (author)
- Ludwig-Maximilian University of Munich
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- Abicht, Jan Michael (author)
- University Hospital Munich
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- Brenner, Paolo (author)
- University Hospital Munich
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 7 s.
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In: Journal of Heart and Lung Transplantation. - : Elsevier BV. - 1053-2498. ; 39:8, s. 751-757
- Related links:
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http://dx.doi.org/10...
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http://www.jhltonlin...
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Abstract
Subject headings
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- Background: The demand for donated human hearts far exceeds the number available. Xenotransplantation of genetically modified porcine organs provides an alternative. In 2000, an Advisory Board of the International Society for Heart and Lung Transplantation set the benchmark for commencing clinical cardiac xenotransplantation as consistent 60% survival of non-human primates after life-supporting porcine heart transplantations. Recently, we reported the stepwise optimization of pig-to-baboon orthotopic cardiac xenotransplantation finally resulting in consistent success, with 4 recipients surviving 90 (n = 2), 182, and 195 days. Here, we report on 4 additional recipients, supporting the efficacy of our procedure. Results: The first 2 additional recipients succumbed to porcine cytomegalovirus (PCMV) infections on Days 15 and 27, respectively. In 2 further experiments, PCMV infections were successfully avoided, and 3-months survival was achieved. Throughout all the long-term experiments, heart, liver, and renal functions remained within normal ranges. Post-mortem cardiac diameters were slightly increased when compared with that at the time of transplantation but with no detrimental effect. There were no signs of thrombotic microangiopathy. The current regimen enabled the prolonged survival and function of orthotopic cardiac xenografts in altogether 6 of 8 baboons, of which 4 were now added. These results exceed the threshold set by the Advisory Board of the International Society for Heart and Lung Transplantation. Conclusions: The results of our current and previous experimental cardiac xenotransplantations together fulfill for the first time the pre-clinical efficacy suggestions. PCMV-positive donor animals must be avoided.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- costimulation blockade
- graft growth
- heart preservation
- orthotopic heart transplantation
- xenotransplantation
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Reichart, Bruno
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Längin, Matthias
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Radan, Julia
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Mokelke, Maren
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Buttgereit, Ines
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Ying, Jiawei
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show more...
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Fresch, Ann Kath ...
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Mayr, Tanja
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Issl, Lara
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Buchholz, Stefan
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Michel, Sebastia ...
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Ellgass, Reinhar ...
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Mihalj, Maks
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Egerer, Stefanie
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Baehr, Andrea
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Kessler, Barbara
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Kemter, Elisabet ...
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Kurome, Mayuko
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Zakhartchenko, V ...
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Steen, Stig
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Sjöberg, Trygve
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Paskevicius, Aud ...
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Krüger, Luise
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Fiebig, Uwe
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Denner, Joachim
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Godehardt, Anton ...
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Tönjes, Ralf R.
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Milusev, Anastas ...
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Rieben, Robert
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Sfriso, Riccardo
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Walz, Christoph
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Kirchner, Thomas
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Ayares, David
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Lampe, Karen
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Schönmann, Uwe
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Hagl, Christian
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Wolf, Eckhard
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Klymiuk, Nikolai
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Abicht, Jan Mich ...
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Brenner, Paolo
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Journal of Heart ...
- By the university
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Lund University