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Concurrent stem- an...
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Safi, FatemehLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
(author)
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
- Article/chapterEnglish2022
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LIBRIS-ID:oai:lup.lub.lu.se:b44c023b-695f-4c55-8c83-b747fa1f3b6e
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https://lup.lub.lu.se/record/b44c023b-695f-4c55-8c83-b747fa1f3b6eURI
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https://doi.org/10.1016/j.celrep.2022.110798DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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The emerging notion of hematopoietic stem and progenitor cells (HSPCs) as a low-primed cloud without sharply demarcated gene expression programs raises the question on how cellular-fate options emerge and at which stem-like stage lineage priming is initiated. Here, we investigate single-cell chromatin accessibility of Lineage-, cKit+, and Sca1+ (LSK) HSPCs spanning the early differentiation landscape. Application of a signal-processing algorithm to detect transition points corresponding to massive alterations in accessibility of 571 transcription factor motifs reveals a population of LSK FMS-like tyrosine kinase 3 (Flt3)intCD9high cells that concurrently display stem-like and lineage-affiliated chromatin signatures, pointing to a simultaneous gain of both lympho-myeloid and megakaryocyte-erythroid programs. Molecularly and functionally, these cells position between stem cells and committed progenitors and display multi-lineage capacity in vitro and in vivo but lack self-renewal activity. This integrative molecular analysis resolves the heterogeneity of cells along hematopoietic differentiation and permits investigation of chromatin-mediated transition between multipotency and lineage restriction.
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Dhapola, ParasharLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)pa1204dh
(author)
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Warsi, SarahLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematopoes och genterapi,Forskargrupper vid Lunds universitet,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Hematopoiesis and Gene Therapy,Lund University Research Groups(Swepub:lu)med-swr
(author)
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Sommarin, MikaelLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Utvecklingslymfopoes och leukemi,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Developmental lymphopoiesis and leukemia(Swepub:lu)immu-mls
(author)
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Erlandsson, EvaLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-ees
(author)
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Ungerbäck, JonasLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär lymfopoes,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Molecular Lymphopoiesis,Lund University Research Groups(Swepub:lu)jo5638un
(author)
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Warfvinge, RebeccaLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-rwi
(author)
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Sitnicka, EwaLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Lymfocytutveckling och reglering,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lymphoid Development and Regulation,Lund University Research Groups(Swepub:lu)molm-esi
(author)
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Bryder, DavidLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Utvecklingshematopoes,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Developmental Hematopoiesis,Lund University Research Groups(Swepub:lu)med-dbr
(author)
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Böiers, CharlottaLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Utvecklingslymfopoes och leukemi,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Developmental lymphopoiesis and leukemia,Lund University Research Groups(Swepub:lu)mig-cbo
(author)
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Thakur, Ram KrishnaLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-rta
(author)
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Karlsson, GöranLund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells and Leukemia,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)molm-gka
(author)
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Avdelningen för molekylär hematologiInstitutionen för laboratoriemedicin
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In:Cell Reports: Elsevier BV39:62211-1247
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Safi, Fatemeh
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Dhapola, Parasha ...
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Warsi, Sarah
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Sommarin, Mikael
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Erlandsson, Eva
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Ungerbäck, Jonas
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Warfvinge, Rebec ...
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Sitnicka, Ewa
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Bryder, David
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Böiers, Charlott ...
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Thakur, Ram Kris ...
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Karlsson, Göran
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