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Controlled-Release ...
Controlled-Release Oxycodone vs. Placebo in the Treatment of Chronic Breathlessness—A Multisite Randomized Placebo Controlled Trial
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- Ferreira, Diana H. (author)
- Flinders University
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- Louw, Sandra (author)
- McCloud Consulting Group
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- McCloud, Philip (author)
- McCloud Consulting Group
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- Fazekas, Belinda (author)
- University of Technology Sydney,Flinders University
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- McDonald, Christine F. (author)
- University of Melbourne,Austin Health
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- Agar, Meera R. (author)
- University of Technology Sydney
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- Clark, Katherine (author)
- University of Sydney
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- McCaffrey, Nikki (author)
- Deakin University
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- Ekström, Magnus (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Breathlessness and chronic respiratory failure,Lund University Research Groups,University of Technology Sydney
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- Currow, David C. (author)
- Flinders University,University of Technology Sydney
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(creator_code:org_t)
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- Elsevier BV, 2020
- 2020
- English 9 s.
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In: Journal of Pain and Symptom Management. - : Elsevier BV. - 0885-3924. ; 59:3, s. 581-589
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http://dx.doi.org/10...
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Abstract
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- Context: Chronic breathlessness is a clinical syndrome that results in significant distress and disability. Morphine can reduce chronic breathlessness when the contributing etiologies are optimally treated. Objectives: Does oxycodone reduce chronic breathlessness compared with placebo? Methods: A multisite, randomized, placebo-controlled, double-blind, parallel-arm, fixed-dose trial of oral controlled-release oxycodone 15 mg (5 mg, eight hourly) or placebo (ACTRN12609000806268 at www.anzctr.org.au). As-needed immediate-release morphine (2.5 mg per dose; six and less doses/day) was available for both arms as required by one ethics committee overseeing the trial. Recruitment occurred from 2010 to 2014 in 14 inpatient and outpatient respiratory, cardiology, and palliative care services across Australia. Participants were adults, with chronic breathlessness (modified Medical Research Council Scale 3 or 4), who were opioid naive. The primary end point was the proportion of people with greater than 15% reduction from baseline in the intensity of breathlessness now (0–100 mm visual analogue scale) comparing arms Days 5–7. Secondary end points were average and worst breathlessness, quality of life, function, and harms. Results: Of 157 participants randomized, 155 were included (74 oxycodone and 81 placebo), but the study did not reach target recruitment. There was difference in neither between groups for the primary outcome (P = 0.489) nor any of the prespecified secondary outcomes. Placebo participants used more as-needed morphine (mean 7.0 vs. 4.2 doses; P ≤ 0.001). Oxycodone participants reported more nausea (P < 0.001). Conclusion: There was no signal of benefit from oxycodone over placebo. Future research should focus on investigating the existence of an opioid class effect on the reduction of chronic breathlessness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
Keyword
- Chronic breathlessness
- effectiveness study
- oxycodone
- palliative care
- placebo study
- randomized controlled trial
- symptom control
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ferreira, Diana ...
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Louw, Sandra
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McCloud, Philip
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Fazekas, Belinda
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McDonald, Christ ...
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Agar, Meera R.
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show more...
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Clark, Katherine
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McCaffrey, Nikki
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Ekström, Magnus
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Currow, David C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Physiotherapy
- Articles in the publication
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Journal of Pain ...
- By the university
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Lund University