Ancestral susceptibility to colorectal cancer

Huhn, Stefanie (author)

Pardini, Barbara (author)

Naccarati, Alessio (author)

Vodicka, Pavel (author)

Hemminki, Kari (author): Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups

Försti, Asta (author): Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups

(creator_code:org_t)

2012-01-30
2012
English.
In: Mutagenesis. - : Oxford University Press (OUP). - 0267-8357 .- 1464-3804. ; 27:2, s. 197-204

Related links:: http://dx.doi.org/10...; show more...; https://academic.oup...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.

By the author/editor: Huhn, Stefanie; Pardini, Barbara; Naccarati, Aless ...; Vodicka, Pavel; Hemminki, Kari; Försti, Asta

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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