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Longitudinal and po...
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Holm, HannesLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Malmö, Sweden
(författare)
Longitudinal and postural changes of blood pressure predict dementia : the Malmö Preventive Project
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-02-11
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Springer Science and Business Media LLC,2017
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:b4954a0a-d2ec-4518-bc6b-d17d3e31522b
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https://lup.lub.lu.se/record/b4954a0a-d2ec-4518-bc6b-d17d3e31522bURI
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https://doi.org/10.1007/s10654-017-0228-0DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-162699URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The role of blood pressure (BP) changes in dementia is debatable. We aimed to analyse how resting and postural BP changes relate to incident dementia over a long-term follow-up. In the prospective population-based Malmö Preventive Project, 18,240 study participants (mean age: 45 ± 7 years, 63% male) were examined between 1974 and 1992 with resting and standing BP measurement, and re-examined between 2002 and 2006 at mean age of 68 ± 6 years with resting BP. A total of 428 participants (2.3%) were diagnosed with dementia through Dec 31, 2009. The association of resting and postural BP changes with risk of dementia was studied using multivariable-adjusted Cox regression models controlling for traditional risk factors. Diastolic BP (DBP) decrease on standing indicated higher risk of dementia [Hazard ratio (HR) per 10 mmHg: 1.22; 95% confidence interval (CI) 1.01–1.44, p = 0.036], which was mainly driven by increased risk in normotensive individuals. Higher systolic (SBP) and diastolic BP at re-examination was associated with lower risk of dementia (HR per 10 mmHg: 0.94; 95% CI 0.89–0.99, p = 0.011; and 0.87; 0.78–0.96, p = 0.006, respectively). Extreme decrease in SBP/DBP between baseline and re-examination (4th quartile; −7 ± 12/−15 ± 7 mmHg, respectively) indicated higher risk of dementia (HR 1.46; 95% CI 1.11–1.93, p = 0.008, and 1.54; 95% CI 1.14–2.08, p = 0.005; respectively) compared with reference group characterised by pronounced BP increase over the same period (1st quartile; +44 ± 13/+15 ± 7 mmHg). Diastolic BP decrease on standing in the middle age, decline in BP between middle-and advanced age, and lower BP in advanced age are independent risk factors of developing dementia.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nägga, KatarinaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden(Swepub:lu)med-kng
(författare)
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Nilsson, Erik D.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden(Swepub:lu)med-exn
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Malmö, Sweden(Swepub:lu)endo-ome
(författare)
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Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden(Swepub:lu)psyk-lmi
(författare)
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Bachus, ErasmusLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Malmö, Sweden(Swepub:lu)med-ebh
(författare)
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Fedorowski, ArturLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Malmö, Sweden(Swepub:lu)med-afr
(författare)
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Magnusson, MartinLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Malmö, Sweden(Swepub:lu)medf-mma
(författare)
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Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Epidemiology: Springer Science and Business Media LLC32:4, s. 327-3360393-29901573-7284
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