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Stability of peptid...
Stability of peptide-HLA-I complexes and tapasin folding facilitation - tools to define immunogenic peptides
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- Geironson Ulfsson, Linda (author)
- Lund University,Lunds universitet,Antigen presentation,Forskargrupper vid Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Antigen Presentation,Lund University Research Groups,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Roder, Gustav (author)
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- Paulsson, Kajsa M (author)
- Lund University,Lunds universitet,Antigen presentation,Forskargrupper vid Lunds universitet,Antigen Presentation,Lund University Research Groups
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(creator_code:org_t)
- 2012-03-28
- 2012
- English.
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In: FEBS Letters. - : Wiley. - 1873-3468 .- 0014-5793. ; 586:9, s. 1336-1343
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Abstract
Subject headings
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- Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes showed small differences in tapasin-facilitation and larger differences in stability. This suggests that the stability of immunogenic peptide-HLA-I complexes vary above an HLA-I allomorph dependent lower limit (e. g. > 2 h for HLA-A*02:01), immunogenicity predicted by tapasin-facilitation may be defined by an equally allomorph unique upper value (e. g. tapasin-facilitation <1.5 for HLA-A*02:01), and variation above the stability-threshold does not directly reflect a variation in tapasin-facilitation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Tapasin
- MHC-I
- Peptide
- Stability
- Vaccine
Publication and Content Type
- art (subject category)
- ref (subject category)
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