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Improved Cerebrospi...
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van Waalwijk van Doorn, Linda J CDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands
(author)
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
- Article/chapterEnglish2017
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LIBRIS-ID:oai:lup.lub.lu.se:b541c926-4f61-4333-a562-f7ff4e8feb6b
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https://lup.lub.lu.se/record/b541c926-4f61-4333-a562-f7ff4e8feb6bURI
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https://doi.org/10.3233/JAD-160668DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74045URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135335796URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Funding Agencies:Aegis of JPND Netherlands Organisation for Health Research and Development (ZonMw), the Netherlands Instituto de Salud Carlos III (ISCIII), Spain PI11/3035 PI11/02425 PI14/01126 Italian Ministry of Health, Italy IG-2014-2354450 Health Research Council of the Academy of Finland, Finland 263193 TUBITAK, Turkey 112S360 Fundacaopara a Ciencia e a Tecnologia (FCT), Portugal PIC/IC/83206/2007 JPND/0005/2011 ZonMW CAVIA project to Verbeek 733050202 Alzheimer Nederland Alzheimer's drug discovery foundation ISAO CIBERNED program (Program 1, Alzheimer Disease) FondoEuropeo de Desarrollo Regional (FEDER) Union Europea Marato TV3 201412.10 Alzheimer's Association IMI Project "PharmaCog", FP7 AXA Research Fund Fondation Universite Pierre et Marie Curie Fondation pour la Recherche sur Alzheimer, Paris, France Ce travail a beneficie d'une aide de l'Etat, program "Investissements d'avenir" ANR-10-IAIHU-06 Swiss National Science Foundation Dutch national 'Deltaplan for Dementia' Una manera de hacer Europa
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Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF Aβ42 levels inversely correlated to VV/TIV in the whole study population (Aβ42: r=-0.28; p<0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r=-0.15; p-tau: r=-0.13; both p<0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF Aβ42 alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF Aβ42 levels.
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Gispert, Juan D.Pompeu Fabra University
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Kuiperij, H. BeaRadboud University Nijmegen
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Claassen, Jurgen A H RRadboud University Nijmegen,University of Milan
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Arighi, AndreaUniversity of Milan
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Baldeiras, InêsUniversity Hospital of Coimbra
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Blennow, KajSahlgrenska University Hospital
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Bozzali, MarcoIRCCS Fondazione Santa Lucia
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Castelo-Branco, MiguelUniversity of Coimbra
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Cavedo, EnricaParis-Sorbonne University
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Emek-Savaş, Derya D.
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Eren, Erden
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Eusebi, Paolo
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Farotti, Lucia
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Fenoglio, Chiara
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Ormaechea, Juan Fortea
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Freund-Levi, Yvonne,1956-Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden(Swepub:oru)yfi
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Frisoni, Giovanni B
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Galimberti, Daniela
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Genc, Sermin
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Greco, Viviana
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Hampel, Harald
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Herukka, Sanna-Kaisa
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Liu, Yawu
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Lladó, Albert
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Lleó, Alberto
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Nobili, Flavio M.
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Oguz, Kader K.
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Parnetti, Lucilla
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Pereira, João
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Picco, Agnese
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Pikkarainen, Maria
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De Oliveira, Catarina Resende
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Saka, Esen
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Salvadori, Nicola
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Sanchez-Valle, Raquel
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Santana, Isabel
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Scarpini, Elio
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Scheltens, Philip
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Soininen, Hilkka
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Tarducci, Roberto
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Teunissen, Charlotte
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Tsolaki, Magda
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Urbani, Andrea
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Vilaplana, Eduard
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Visser, Pieter Jelle
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Wallin, Asa K.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-was
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Yener, Görsev
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Molinuevo, José L
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Meulenbroek, Olga
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Verbeek, MarcelDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands
(author)
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Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The NetherlandsPompeu Fabra University
(creator_code:org_t)
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In:Journal of Alzheimer's Disease: IOS Press56:2, s. 543-5551387-28771875-8908
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van Waalwijk van ...
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Gispert, Juan D.
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Kuiperij, H. Bea
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Claassen, Jurgen ...
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Arighi, Andrea
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Baldeiras, Inês
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Blennow, Kaj
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Bozzali, Marco
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Castelo-Branco, ...
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Cavedo, Enrica
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Emek-Savaş, Dery ...
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Eren, Erden
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Eusebi, Paolo
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Farotti, Lucia
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Fenoglio, Chiara
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Ormaechea, Juan ...
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Freund-Levi, Yvo ...
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Frisoni, Giovann ...
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Galimberti, Dani ...
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Genc, Sermin
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Greco, Viviana
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Hampel, Harald
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Herukka, Sanna-K ...
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Liu, Yawu
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Lladó, Albert
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Lleó, Alberto
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Nobili, Flavio M ...
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Oguz, Kader K.
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Parnetti, Lucill ...
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Pereira, João
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Picco, Agnese
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Pikkarainen, Mar ...
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De Oliveira, Cat ...
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Saka, Esen
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Salvadori, Nicol ...
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Sanchez-Valle, R ...
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Santana, Isabel
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Scarpini, Elio
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Scheltens, Phili ...
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Soininen, Hilkka
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Tarducci, Robert ...
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Teunissen, Charl ...
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Tsolaki, Magda
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Urbani, Andrea
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Vilaplana, Eduar ...
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Visser, Pieter J ...
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Wallin, Asa K.
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Yener, Görsev
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Molinuevo, José ...
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Meulenbroek, Olg ...
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Verbeek, Marcel
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Journal of Alzhe ...
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Lund University
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Örebro University
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Karolinska Institutet