SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:b541c926-4f61-4333-a562-f7ff4e8feb6b"
 

Search: onr:"swepub:oai:lup.lub.lu.se:b541c926-4f61-4333-a562-f7ff4e8feb6b" > Improved Cerebrospi...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • van Waalwijk van Doorn, Linda J CDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands (author)

Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • IOS Press,2017
  • 13 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:b541c926-4f61-4333-a562-f7ff4e8feb6b
  • https://lup.lub.lu.se/record/b541c926-4f61-4333-a562-f7ff4e8feb6bURI
  • https://doi.org/10.3233/JAD-160668DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74045URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135335796URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Funding Agencies:Aegis of JPND  Netherlands Organisation for Health Research and Development (ZonMw), the Netherlands  Instituto de Salud Carlos III (ISCIII), Spain  PI11/3035  PI11/02425  PI14/01126 Italian Ministry of Health, Italy  IG-2014-2354450 Health Research Council of the Academy of Finland, Finland  263193 TUBITAK, Turkey  112S360 Fundacaopara a Ciencia e a Tecnologia (FCT), Portugal  PIC/IC/83206/2007  JPND/0005/2011 ZonMW  CAVIA project to Verbeek  733050202 Alzheimer Nederland  Alzheimer's drug discovery foundation  ISAO  CIBERNED program (Program 1, Alzheimer Disease)  FondoEuropeo de Desarrollo Regional (FEDER)  Union Europea  Marato TV3  201412.10 Alzheimer's Association  IMI Project "PharmaCog", FP7  AXA Research Fund  Fondation Universite Pierre et Marie Curie  Fondation pour la Recherche sur Alzheimer, Paris, France  Ce travail a beneficie d'une aide de l'Etat, program "Investissements d'avenir"  ANR-10-IAIHU-06 Swiss National Science Foundation  Dutch national 'Deltaplan for Dementia'  Una manera de hacer Europa 
  • Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF Aβ42 levels inversely correlated to VV/TIV in the whole study population (Aβ42: r=-0.28; p<0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r=-0.15; p-tau: r=-0.13; both p<0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF Aβ42 alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF Aβ42 levels.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gispert, Juan D.Pompeu Fabra University (author)
  • Kuiperij, H. BeaRadboud University Nijmegen (author)
  • Claassen, Jurgen A H RRadboud University Nijmegen,University of Milan (author)
  • Arighi, AndreaUniversity of Milan (author)
  • Baldeiras, InêsUniversity Hospital of Coimbra (author)
  • Blennow, KajSahlgrenska University Hospital (author)
  • Bozzali, MarcoIRCCS Fondazione Santa Lucia (author)
  • Castelo-Branco, MiguelUniversity of Coimbra (author)
  • Cavedo, EnricaParis-Sorbonne University (author)
  • Emek-Savaş, Derya D. (author)
  • Eren, Erden (author)
  • Eusebi, Paolo (author)
  • Farotti, Lucia (author)
  • Fenoglio, Chiara (author)
  • Ormaechea, Juan Fortea (author)
  • Freund-Levi, Yvonne,1956-Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden(Swepub:oru)yfi (author)
  • Frisoni, Giovanni B (author)
  • Galimberti, Daniela (author)
  • Genc, Sermin (author)
  • Greco, Viviana (author)
  • Hampel, Harald (author)
  • Herukka, Sanna-Kaisa (author)
  • Liu, Yawu (author)
  • Lladó, Albert (author)
  • Lleó, Alberto (author)
  • Nobili, Flavio M. (author)
  • Oguz, Kader K. (author)
  • Parnetti, Lucilla (author)
  • Pereira, João (author)
  • Picco, Agnese (author)
  • Pikkarainen, Maria (author)
  • De Oliveira, Catarina Resende (author)
  • Saka, Esen (author)
  • Salvadori, Nicola (author)
  • Sanchez-Valle, Raquel (author)
  • Santana, Isabel (author)
  • Scarpini, Elio (author)
  • Scheltens, Philip (author)
  • Soininen, Hilkka (author)
  • Tarducci, Roberto (author)
  • Teunissen, Charlotte (author)
  • Tsolaki, Magda (author)
  • Urbani, Andrea (author)
  • Vilaplana, Eduard (author)
  • Visser, Pieter Jelle (author)
  • Wallin, Asa K.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-was (author)
  • Yener, Görsev (author)
  • Molinuevo, José L (author)
  • Meulenbroek, Olga (author)
  • Verbeek, MarcelDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands (author)
  • Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The NetherlandsPompeu Fabra University (creator_code:org_t)

Related titles

  • In:Journal of Alzheimer's Disease: IOS Press56:2, s. 543-5551387-28771875-8908

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view