IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat

Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.

Jacobs, C.University of Washington (author)
Baker, P.University of Washington (author)
Baskin, D. G.University of Washington (author)
Dower, S.University of Washington (author)
Lernmark, A.Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,University of Washington(Swepub:lu)endo-ale (author)
Toivola, B.University of Washington (author)
Vertrees, S.University of Washington (author)
Wilson, D.University of Washington (author)
University of WashingtonInstitutionen för translationell medicin (creator_code:org_t)

By the author/editor: Wilson, C. A.; Jacobs, C.; Baker, P.; Baskin, D. G.; Dower, S.; Lernmark, A.; show more...; Toivola, B.; Vertrees, S.; Wilson, D.; show less...

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