Search: onr:"swepub:oai:lup.lub.lu.se:b57a0e47-0246-4160-819f-c51515400cfc" > IL-1β modulation of...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02499naa a2200325 4500 | |
001 | oai:lup.lub.lu.se:b57a0e47-0246-4160-819f-c51515400cfc | |
003 | SwePub | |
008 | 190911s1990 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/b57a0e47-0246-4160-819f-c51515400cfc2 URI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Wilson, C. A.u University of Washington4 aut |
245 | 1 0 | a IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat |
264 | 1 | c 1990 |
520 | a Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner. | |
700 | 1 | a Jacobs, C.u University of Washington4 aut |
700 | 1 | a Baker, P.u University of Washington4 aut |
700 | 1 | a Baskin, D. G.u University of Washington4 aut |
700 | 1 | a Dower, S.u University of Washington4 aut |
700 | 1 | a Lernmark, A.u Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,University of Washington4 aut0 (Swepub:lu)endo-ale |
700 | 1 | a Toivola, B.u University of Washington4 aut |
700 | 1 | a Vertrees, S.u University of Washington4 aut |
700 | 1 | a Wilson, D.u University of Washington4 aut |
710 | 2 | a University of Washingtonb Institutionen för translationell medicin4 org |
773 | 0 | t Journal of Immunologyg 144:10, s. 3784-3788q 144:10<3784-3788x 0022-1767 |
856 | 4 | u https://www.jimmunol.org/content/jimmunol/144/10/3784.full.pdfy FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/b57a0e47-0246-4160-819f-c51515400cfc |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view