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IL-1β modulation of...
IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat
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- Wilson, C. A. (author)
- University of Washington
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- Jacobs, C. (author)
- University of Washington
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- Baker, P. (author)
- University of Washington
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- Baskin, D. G. (author)
- University of Washington
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- Dower, S. (author)
- University of Washington
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- Lernmark, A. (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,University of Washington
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- Toivola, B. (author)
- University of Washington
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- Vertrees, S. (author)
- University of Washington
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- Wilson, D. (author)
- University of Washington
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(creator_code:org_t)
- 1990
- 1990
- English.
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In: Journal of Immunology. - 0022-1767. ; 144:10, s. 3784-3788
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Abstract
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- Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner.
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- art (subject category)
- ref (subject category)
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