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Poly(ethylene glyco...
Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.
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Barany, George (author)
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Albericio, Fernando (author)
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Kates, Steven (author)
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- Kempe, Maria (author)
- Lund University,Lunds universitet,Nanomedicin och biomaterial,Forskargrupper vid Lunds universitet,Nanomedicine and Biomaterials,Lund University Research Groups
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Harris, J.M. (editor)
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Zalipsky, S. (editor)
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(creator_code:org_t)
- 1997-07-23
- 1997
- English.
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In: Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series. - Washington, DC : American Chemical Society. - 9780841235373 ; 680, s. 239-264
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- kap (subject category)
- pop (subject category)
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