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Heritability of Atr...
Heritability of Atrial Fibrillation
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- Weng, Lu Chen (author)
- Massachusetts Institute of Technology
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- Choi, Seung Hoan (author)
- Massachusetts Institute of Technology
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- Klarin, Derek (author)
- Massachusetts Institute of Technology
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- Smith, J. Gustav (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Broad Institute,Massachusetts Institute of Technology
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- Loh, Po Ru (author)
- Massachusetts Institute of Technology,Harvard University
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- Chaffin, Mark (author)
- Massachusetts Institute of Technology
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- Roselli, Carolina (author)
- Massachusetts Institute of Technology
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- Hulme, Olivia L. (author)
- Massachusetts Institute of Technology
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- Lunetta, Kathryn L. (author)
- Boston University
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- Dupuis, Josée (author)
- Boston University
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- Benjamin, Emelia J. (author)
- Boston University
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- Newton-Cheh, Christopher (author)
- Massachusetts Institute of Technology
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- Kathiresan, Sekar (author)
- Massachusetts Institute of Technology
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- Ellinor, Patrick T. (author)
- Massachusetts Institute of Technology,Massachusetts General Hospital
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- Lubitz, Steven A. (author)
- Massachusetts Institute of Technology,Massachusetts General Hospital
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Circulation: Cardiovascular Genetics. - 1942-325X. ; 10:6
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http://dx.doi.org/10...
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Abstract
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- Background - Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. Methods and Results - We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2 g) using data from 120 286 unrelated individuals of European ancestry (2987 with AF) in the population-based UK Biobank. We ascertained AF based on self-report, medical record billing codes, procedure codes, and death records. We estimated h2 g using a variance components method with variants having a minor allele frequency ≥1%. We evaluated h2 g in age, sex, and genomic strata of interest. The h2 g for AF was 22.1% (95% confidence interval, 15.6%-28.5%) and was similar for early- versus older-onset AF (≤65 versus >65 years of age), as well as for men and women. The proportion of AF variance explained by genetic variation was mainly accounted for by common (minor allele frequency, ≥5%) variants (20.4%; 95% confidence interval, 15.1%-25.6%). Only 6.4% (95% confidence interval, 5.1%-7.7%) of AF variance was attributed to variation within known AF susceptibility, cardiac arrhythmia, and cardiomyopathy gene regions. Conclusions - Genetic variation contributes substantially to AF risk. The risk for AF conferred by genomic variation is similar to that observed for several other cardiovascular diseases. Established AF loci only explain a moderate proportion of disease risk, suggesting that further genetic discovery, with an emphasis on common variation, is warranted to understand the causal genetic basis of AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- atrial fibrillation
- epidemiology
- genome-wide association study
- genomics
- medical records
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Weng, Lu Chen
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Choi, Seung Hoan
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Klarin, Derek
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Smith, J. Gustav
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Loh, Po Ru
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Chaffin, Mark
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show more...
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Roselli, Carolin ...
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Hulme, Olivia L.
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Lunetta, Kathryn ...
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Dupuis, Josée
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Benjamin, Emelia ...
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Newton-Cheh, Chr ...
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Kathiresan, Seka ...
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Ellinor, Patrick ...
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Lubitz, Steven A ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation: Car ...
- By the university
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Lund University